N-Boc-(R)-4-phenyloxyphenylglycine methyl ester

Base Information

Chemical Name:N-Boc-(R)-4-phenyloxyphenylglycine methyl ester
CAS No.:1268694-24-1
Molecular Formula:C₂₀H₂₃NO₅
Molecular Weight:357.406
Hs Code.:

Synonyms:N-Boc-(R)-4-phenyloxyphenylglycine methyl ester

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Chemical Property of N-Boc-(R)-4-phenyloxyphenylglycine methyl ester

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Technology Process of N-Boc-(R)-4-phenyloxyphenylglycine methyl ester

There total 4 articles about N-Boc-(R)-4-phenyloxyphenylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: diphenyliodonium tetrafluoroborate

: 143323-49-3,141518-55-0
(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

: 1268694-24-1
N-Boc-(R)-4-phenyloxyphenylglycine methyl ester

Guidance literature:: (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate; With potassium tert-butylate; In dichloromethane; at 0 ℃; for 0.25h;

diphenyliodonium tetrafluoroborate; In dichloromethane; at 40 ℃; for 0.333333h;
DOI:10.1021/ol200265t

Reference yield: 99.0%

: diphenyliodonium tetrafluoroborate

: 141190-94-5,143978-88-5
(R)-N-(tert-butoxycarbonyl)phenylglycine methyl ester

: 1268694-24-1
N-Boc-(R)-4-phenyloxyphenylglycine methyl ester

Guidance literature:: (R)-N-(tert-butoxycarbonyl)phenylglycine methyl ester; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 0.25h;

diphenyliodonium tetrafluoroborate; In tetrahydrofuran; at 40 ℃; for 0.333333h;
DOI:10.1002/chem.201201645

Reference yield:

: 591-50-4
iodobenzene

: 1268694-24-1
N-Boc-(R)-4-phenyloxyphenylglycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C

1.2: 0.25 h / 20 °C

2.1: potassium tert-butylate / dichloromethane / 0.25 h / 0 °C

2.2: 0.33 h / 40 °C

With boron trifluoride diethyl etherate; potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/ol200265t