1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS)

Base Information

Chemical Name:1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS)
CAS No.:323178-30-9
Molecular Formula:C14H18 N2 O4 S
Molecular Weight:310.37
Hs Code.:
Mol file:323178-30-9.mol

Synonyms:1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS)

Suppliers and Price of 1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(ALPHA-S)-1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID-6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-1,1-DIOXIDE METHYL ESTER 95.00%
5MG
$ 496.76

Total 2 raw suppliers

Chemical Property of 1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS)

Chemical Property:

Boiling Point:465.4±55.0 °C(Predicted)
PKA:11.11±0.20(Predicted)
PSA：84.09000
Density:1.272±0.06 g/cm3(Predicted)
LogP:1.82440

Purity/Quality:

97% ^*data from raw suppliers

(ALPHA-S)-1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID-6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-1,1-DIOXIDE METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS)

There total 4 articles about 1,2,7-THIADIAZEPINE-2(3H)-ACETIC ACID, 6,7-DIHYDRO-ALPHA-(PHENYLMETHYL)-, METHYL ESTER, 1,1-DIOXIDE, (ALPHAS) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 323178-29-6
2-(2S)-[(2,3,6,7-tetrahydro-1,2,7-thiadiazepine-1,1-dioxido-7-tert-butyloxycarbonyl-2-yl)]-3-phenylpropionic acid methyl ester

: 323178-30-9
(S)-2-(1,1-dioxo-1,3,6,7-tetrahydro-1λ⁶-[1,2,7]thiadiazepin-2-yl)-3-phenylpropionic acid methyl ester

Guidance literature:: at 20 ℃; for 36h;
DOI:10.1016/S0040-4020(00)00885-1

Reference yield:

: 139059-69-1
<(S)(+)> methyl -phenylalaninate

: 323178-30-9
(S)-2-(1,1-dioxo-1,3,6,7-tetrahydro-1λ⁶-[1,2,7]thiadiazepin-2-yl)-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / K₂CO₃ / acetone / 12 h / Heating

2: 84 percent / RuCl₂(Cy₃P)2CHPh / CH₂Cl₂ / Heating

3: 83 percent / 36 h / 20 °C

With Grubbs catalyst first generation; potassium carbonate; In dichloromethane; acetone; 1: Alkylation / 2: ring-closing metathesis / 3: amide cleavage;
DOI:10.1016/S0040-4020(00)00885-1

Reference yield:

: 323178-28-5
N,N'-bis(2-propenyl)-N-(tert-butoxycarbonylsulfonyl)-L-phenylalanine methyl ester

: 323178-30-9
(S)-2-(1,1-dioxo-1,3,6,7-tetrahydro-1λ⁶-[1,2,7]thiadiazepin-2-yl)-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / RuCl₂(Cy₃P)2CHPh / CH₂Cl₂ / Heating

2: 83 percent / 36 h / 20 °C

With Grubbs catalyst first generation; In dichloromethane; 1: ring-closing metathesis / 2: amide cleavage;
DOI:10.1016/S0040-4020(00)00885-1