(4S,5S)-5-<(benzyloxycarbonyl)(methyl)amino>-2,2-dimethyl-4-phenyl-1,3-dioxan

Base Information

Chemical Name:(4S,5S)-5-<(benzyloxycarbonyl)(methyl)amino>-2,2-dimethyl-4-phenyl-1,3-dioxan
CAS No.:127086-92-4
Molecular Formula:C₂₁H₂₅NO₄
Molecular Weight:355.434
Hs Code.:

Synonyms:(4S,5S)-5-<(benzyloxycarbonyl)(methyl)amino>-2,2-dimethyl-4-phenyl-1,3-dioxan

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5S)-5-<(benzyloxycarbonyl)(methyl)amino>-2,2-dimethyl-4-phenyl-1,3-dioxan

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Technology Process of (4S,5S)-5-<(benzyloxycarbonyl)(methyl)amino>-2,2-dimethyl-4-phenyl-1,3-dioxan

There total 4 articles about (4S,5S)-5-<(benzyloxycarbonyl)(methyl)amino>-2,2-dimethyl-4-phenyl-1,3-dioxan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124686-47-1
(4S,5S)-(+)-2,2-Dimethyl-5-methylamino-4-phenyl-1,3-dioxan

: 501-53-1,94274-21-2
benzyl chloroformate

: 127086-92-4
(4S,5S)-5-<(benzyloxycarbonyl)(methyl)amino>-2,2-dimethyl-4-phenyl-1,3-dioxan

Guidance literature:: With triethylamine; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1002/(SICI)1522-2675(19981007)81:10<1803::AID-HLCA1803>3.0.CO;2-4

Reference yield:

: 28143-91-1
(1S,2S)-2-amino-1-phenyl-1,3-diol

: 127086-92-4
(4S,5S)-5-<(benzyloxycarbonyl)(methyl)amino>-2,2-dimethyl-4-phenyl-1,3-dioxan

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / NaHCO₃ / H₂O / Ambient temperature

2: TsOH, 4A sieves / acetone / Ambient temperature

3: 1.) NaH / 1.) DMF, 20 min

With 4 A molecular sieve; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; In water; acetone;
DOI:10.1021/ja00175a039

Reference yield:

: 127102-27-6
benzyl L-threo-1,3-dihydroxy-1-phenylpropan-2-yl-carbamate

: 127086-92-4
(4S,5S)-5-<(benzyloxycarbonyl)(methyl)amino>-2,2-dimethyl-4-phenyl-1,3-dioxan

Guidance literature:: Multi-step reaction with 2 steps

1: TsOH, 4A sieves / acetone / Ambient temperature

2: 1.) NaH / 1.) DMF, 20 min

With 4 A molecular sieve; sodium hydride; toluene-4-sulfonic acid; In acetone;
DOI:10.1021/ja00175a039