2-[4-(5-Ethyl-2-oxo-2,3-dihydro-1H-imidazole-4-carbonyl)-phenyl]-isoindole-1,3-dione

Base Information

• Chemical Name: 2-[4-(5-Ethyl-2-oxo-2,3-dihydro-1H-imidazole-4-carbonyl)-phenyl]-isoindole-1,3-dione
• CAS No.: 173375-22-9
• Molecular Formula: C₂₀H₁₅N₃O₄
• Molecular Weight: 361.357

Synonyms:2-[4-(5-Ethyl-2-oxo-2,3-dihydro-1H-imidazole-4-carbonyl)-phenyl]-isoindole-1,3-dione

Chemical Property of 2-[4-(5-Ethyl-2-oxo-2,3-dihydro-1H-imidazole-4-carbonyl)-phenyl]-isoindole-1,3-dione

Chemical Property:

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Technology Process of 2-[4-(5-Ethyl-2-oxo-2,3-dihydro-1H-imidazole-4-carbonyl)-phenyl]-isoindole-1,3-dione

There total 2 articles about 2-[4-(5-Ethyl-2-oxo-2,3-dihydro-1H-imidazole-4-carbonyl)-phenyl]-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,2-dihydro-4-ethyl-2H-imidazol-2-one (83962-06-5) + 4–(1,3-dioxoisoindolin-2-yl)benzoyl chloride (5383-83-5) → 2-[4-(5-Ethyl-2-oxo-2,3-dihydro-1H-imidazole-4-carbonyl)-phenyl]-isoindole-1,3-dione (173375-22-9)

Guidance literature:

With aluminium trichloride; In nitrobenzene; at 60 ℃; for 6h;

DOI:10.1002/ardp.19953281005

Reference yield:

5-Ethyl-1,3-dihydro-2-oxo-3H-imidazole-4-carboxylate (87214-70-8) → 2-[4-(5-Ethyl-2-oxo-2,3-dihydro-1H-imidazole-4-carbonyl)-phenyl]-isoindole-1,3-dione (173375-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / Ba(OH)2 / Heating

2: 95 percent / AlCl₃ / nitrobenzene / 6 h / 60 °C

With barium dihydroxide; aluminium trichloride; In nitrobenzene;

DOI:10.1002/ardp.19953281005

Reference yield: 94.0%

2-[4-(5-Ethyl-2-oxo-2,3-dihydro-1H-imidazole-4-carbonyl)-phenyl]-isoindole-1,3-dione (173375-22-9) → 4-(4-Aminobenzoyl)-1,3-dihydro-5-ethyl-3H-imidazol-2-one (173375-24-1)

Guidance literature:

With sodium carbonate; hydrazine hydrate; for 10h; Ambient temperature;

DOI:10.1002/ardp.19953281005

upstream raw materials:

1,2-dihydro-4-ethyl-2H-imidazol-2-one

4–(1,3-dioxoisoindolin-2-yl)benzoyl chloride

5-Ethyl-1,3-dihydro-2-oxo-3H-imidazole-4-carboxylate

Downstream raw materials:

4-(4-Aminobenzoyl)-1,3-dihydro-5-ethyl-3H-imidazol-2-one

C₂₄H₃₁N₇O₄

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