Technology Process of (2R)-2-phenyl-2-[(3S)-3-(prop-2-en-1-yl)-2,3,4,5-tetrahydro-1H-2-benzazepin-2-yl]ethanol
There total 7 articles about (2R)-2-phenyl-2-[(3S)-3-(prop-2-en-1-yl)-2,3,4,5-tetrahydro-1H-2-benzazepin-2-yl]ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
aluminum (III) chloride; lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
DOI:10.1016/j.tetasy.2010.03.019
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate; palladium diacetate; N-benzyl-N,N,N-triethylammonium chloride / N,N-dimethyl-formamide / 5.5 h / 45 °C
2.1: chloroform / Reflux
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -80 °C / Inert atmosphere
3.2: 1.25 h / Inert atmosphere
4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / Inert atmosphere
4.2: 20.25 h / 20 °C / Inert atmosphere; Reflux
5.1: hydrogenchloride / water; chloroform / 16 h / 20 °C
6.1: titanium tetrachloride / dichloromethane / 0.08 h / 70 °C / Inert atmosphere; Microwave irradiation
7.1: aluminum (III) chloride; lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; aluminum (III) chloride; lithium aluminium tetrahydride; n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate; titanium tetrachloride; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1039/c5ob00731c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / Inert atmosphere
1.2: 20.25 h / 20 °C / Inert atmosphere; Reflux
2.1: hydrogenchloride / water; chloroform / 16 h / 20 °C
3.1: titanium tetrachloride / dichloromethane / 0.08 h / 70 °C / Inert atmosphere; Microwave irradiation
4.1: aluminum (III) chloride; lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
With
hydrogenchloride; aluminum (III) chloride; lithium aluminium tetrahydride; titanium tetrachloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; dichloromethane; chloroform; water;
DOI:10.1039/c5ob00731c