Technology Process of Piperazine, 1-ethyl-3-methyl-, (3R)- (9CI)
There total 5 articles about Piperazine, 1-ethyl-3-methyl-, (3R)- (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1: 100 percent / Et3N / ethyl acetate / 1 h / 0 °C
2: 58 percent / OsO4; NaIO4 / acetone; H2O / 3 h / 20 °C
3: 64 percent / AcOH; sodium triacetoxyborohydride; 4A MS / 1,2-dichloro-ethane / 15 h / 0 - 20 °C
4: LiALH4 / diethyl ether / 0 - 20 °C
5: H2; Pd(OH)2; HCl / ethanol / 18 h
With
hydrogenchloride; palladium dihydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; triethylamine;
In
diethyl ether; ethanol; water; ethyl acetate; 1,2-dichloro-ethane; acetone;
1: Acylation / 2: Oxidation / 3: Cyclization / 4: Reduction / 5: debenzylation;
DOI:10.1016/S0040-4039(00)01565-3
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 64 percent / AcOH; sodium triacetoxyborohydride; 4A MS / 1,2-dichloro-ethane / 15 h / 0 - 20 °C
2: LiALH4 / diethyl ether / 0 - 20 °C
3: H2; Pd(OH)2; HCl / ethanol / 18 h
With
hydrogenchloride; palladium dihydroxide; lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; acetic acid;
In
diethyl ether; ethanol; 1,2-dichloro-ethane;
1: Cyclization / 2: Reduction / 3: debenzylation;
DOI:10.1016/S0040-4039(00)01565-3
