1N-[3'-O-benzyl-4'-C-(4,4-dimethoxytrityloxymethyl)-3'-C-(2-hydroxyethyl)-5'-O-methanesulfonyl-2'-deoxy-β-D-xylofuranosyl]thymine

Base Information

• Chemical Name: 1N-[3'-O-benzyl-4'-C-(4,4-dimethoxytrityloxymethyl)-3'-C-(2-hydroxyethyl)-5'-O-methanesulfonyl-2'-deoxy-β-D-xylofuranosyl]thymine
• CAS No.: 1112393-54-0
• Molecular Formula: C₄₂H₄₆N₂O₁₁S
• Molecular Weight: 786.9
• Mol file: 1112393-54-0.mol

Synonyms:1N-[3'-O-benzyl-4'-C-(4,4-dimethoxytrityloxymethyl)-3'-C-(2-hydroxyethyl)-5'-O-methanesulfonyl-2'-deoxy-β-D-xylofuranosyl]thymine

Chemical Property of 1N-[3'-O-benzyl-4'-C-(4,4-dimethoxytrityloxymethyl)-3'-C-(2-hydroxyethyl)-5'-O-methanesulfonyl-2'-deoxy-β-D-xylofuranosyl]thymine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1N-[3'-O-benzyl-4'-C-(4,4-dimethoxytrityloxymethyl)-3'-C-(2-hydroxyethyl)-5'-O-methanesulfonyl-2'-deoxy-β-D-xylofuranosyl]thymine

There total 1 articles about 1N-[3'-O-benzyl-4'-C-(4,4-dimethoxytrityloxymethyl)-3'-C-(2-hydroxyethyl)-5'-O-methanesulfonyl-2'-deoxy-β-D-xylofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C42H44N2O11S → 1N-[3'-O-benzyl-4'-C-(4,4-dimethoxytrityloxymethyl)-3'-C-(2-hydroxyethyl)-5'-O-methanesulfonyl-2'-deoxy-β-D-xylofuranosyl]thymine (1112393-54-0)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 - 20 ℃;

DOI:10.1021/jo8023472

Reference yield: 95.0%

1N-[3'-O-benzyl-4'-C-(4,4-dimethoxytrityloxymethyl)-3'-C-(2-hydroxyethyl)-5'-O-methanesulfonyl-2'-deoxy-β-D-xylofuranosyl]thymine (1112393-54-0) → (1S,6R,8R)-6-benzyloxy-1-(4,4'-dimethoxytrityloxymethyl)-8-(thymin-1-yl)-3,9-dioxabicyclo[4.3.0]nonane (1112393-60-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo8023472

Downstream raw materials:

(1S,6R,8R)-6-benzyloxy-1-(4,4'-dimethoxytrityloxymethyl)-8-(thymin-1-yl)-3,9-dioxabicyclo[4.3.0]nonane