Chloro-acetic acid (R)-2-[(1R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-2-oxo-cycloheptyl]-propyl ester

Base Information

Chemical Name:Chloro-acetic acid (R)-2-[(1R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-2-oxo-cycloheptyl]-propyl ester
CAS No.:161029-72-7
Molecular Formula:C₂₉H₃₉ClO₄Si
Molecular Weight:515.165
Hs Code.:

Synonyms:Chloro-acetic acid (R)-2-[(1R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-2-oxo-cycloheptyl]-propyl ester

Suppliers and Price of Chloro-acetic acid (R)-2-[(1R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-2-oxo-cycloheptyl]-propyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Chloro-acetic acid (R)-2-[(1R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-2-oxo-cycloheptyl]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Chloro-acetic acid (R)-2-[(1R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-2-oxo-cycloheptyl]-propyl ester

There total 4 articles about Chloro-acetic acid (R)-2-[(1R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-2-oxo-cycloheptyl]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 161029-68-1
(3aR,6R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-6-methyl-octahydro-cyclohepta[b]furan-2-one

: 161029-72-7
Chloro-acetic acid (R)-2-[(1R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-2-oxo-cycloheptyl]-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, -78 deg C, 2.) THF, HMPA, -78 deg C to -40 deg C, 20 min

2: 96 percent / LiBH₄ / tetrahydrofuran / 4 h / Heating

3: 86 percent / triethylamine / CH₂Cl₂ / 3 h / -78 °C

4: 1.) (COCl)2, 2.) triethylamine / 1.) DMSO, CH₂Cl₂, -60 deg C, 30 min, 2.) DMSO, CH₂Cl₂, -60 deg C to RT, 1 h

With lithium borohydride; oxalyl dichloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00097a060

Reference yield:

: (2R,5R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-2-((R)-2-hydroxy-1-methyl-ethyl)-5-methyl-cycloheptanol

: 161029-72-7
Chloro-acetic acid (R)-2-[(1R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-2-oxo-cycloheptyl]-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / triethylamine / CH₂Cl₂ / 3 h / -78 °C

2: 1.) (COCl)2, 2.) triethylamine / 1.) DMSO, CH₂Cl₂, -60 deg C, 30 min, 2.) DMSO, CH₂Cl₂, -60 deg C to RT, 1 h

With oxalyl dichloride; triethylamine; In dichloromethane;
DOI:10.1021/ja00097a060

Reference yield:

: 161029-69-2
(3R,3aR,6R,7S,8aR)-7-(tert-Butyl-diphenyl-silanyloxy)-3,6-dimethyl-octahydro-cyclohepta[b]furan-2-one

: 161029-72-7
Chloro-acetic acid (R)-2-[(1R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-methyl-2-oxo-cycloheptyl]-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / LiBH₄ / tetrahydrofuran / 4 h / Heating

2: 86 percent / triethylamine / CH₂Cl₂ / 3 h / -78 °C

3: 1.) (COCl)2, 2.) triethylamine / 1.) DMSO, CH₂Cl₂, -60 deg C, 30 min, 2.) DMSO, CH₂Cl₂, -60 deg C to RT, 1 h

With lithium borohydride; oxalyl dichloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00097a060