N²-(5,6-Dichloro-1H-benzoimidazol-2-yl)-N⁴-(3-ethylaminomethyl-4-methoxy-phenyl)-6-methyl-pyrimidine-2,4-diamine; hydrochloride

Base Information

• Chemical Name: N²-(5,6-Dichloro-1H-benzoimidazol-2-yl)-N⁴-(3-ethylaminomethyl-4-methoxy-phenyl)-6-methyl-pyrimidine-2,4-diamine; hydrochloride
• CAS No.: 86260-58-4
• Molecular Formula: C₂₂H₂₃Cl₂N₇O*2ClH
• Molecular Weight: 545.299

Synonyms:N²-(5,6-Dichloro-1H-benzoimidazol-2-yl)-N⁴-(3-ethylaminomethyl-4-methoxy-phenyl)-6-methyl-pyrimidine-2,4-diamine; hydrochloride

Chemical Property of N²-(5,6-Dichloro-1H-benzoimidazol-2-yl)-N⁴-(3-ethylaminomethyl-4-methoxy-phenyl)-6-methyl-pyrimidine-2,4-diamine; hydrochloride

Chemical Property:

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Technology Process of N²-(5,6-Dichloro-1H-benzoimidazol-2-yl)-N⁴-(3-ethylaminomethyl-4-methoxy-phenyl)-6-methyl-pyrimidine-2,4-diamine; hydrochloride

There total 1 articles about N²-(5,6-Dichloro-1H-benzoimidazol-2-yl)-N⁴-(3-ethylaminomethyl-4-methoxy-phenyl)-6-methyl-pyrimidine-2,4-diamine; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

5-amino-N-ethyl-2-methoxybenzenemethanamine dihydrochloride (51388-03-5) + 5,6-dichloro-N-<4-chloro-6-methyl-2-pyrimidinyl>-1H-benzimidazol-2-amine (42388-69-2) → N2-(5,6-Dichloro-1H-benzoimidazol-2-yl)-N4-(3-ethylaminomethyl-4-methoxy-phenyl)-6-methyl-pyrimidine-2,4-diamine; hydrochloride (86260-58-4)

Guidance literature:

In N,N-dimethyl-formamide; at 110 ℃; for 3h;

DOI:10.1021/jm00363a017

upstream raw materials:

5-amino-N-ethyl-2-methoxybenzenemethanamine dihydrochloride

5,6-dichloro-N-<4-chloro-6-methyl-2-pyrimidinyl>-1H-benzimidazol-2-amine

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