2-acetyl-4-methylene-3-(2-nitro-phenyl)-pentanedioic acid 1-ethyl ester 5-methyl ester

Base Information

Chemical Name:2-acetyl-4-methylene-3-(2-nitro-phenyl)-pentanedioic acid 1-ethyl ester 5-methyl ester
CAS No.:910456-76-7
Molecular Formula:C₁₇H₁₉NO₇
Molecular Weight:349.34
Hs Code.:

Synonyms:2-acetyl-4-methylene-3-(2-nitro-phenyl)-pentanedioic acid 1-ethyl ester 5-methyl ester

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Chemical Property of 2-acetyl-4-methylene-3-(2-nitro-phenyl)-pentanedioic acid 1-ethyl ester 5-methyl ester

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Technology Process of 2-acetyl-4-methylene-3-(2-nitro-phenyl)-pentanedioic acid 1-ethyl ester 5-methyl ester

There total 3 articles about 2-acetyl-4-methylene-3-(2-nitro-phenyl)-pentanedioic acid 1-ethyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 141-97-9
ethyl acetoacetate

: 159763-31-2
methyl 3-acetoxy-2-methylene-3-(2-nitrophenyl)propanoate

: 910456-76-7
2-acetyl-4-methylene-3-(2-nitro-phenyl)-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: methyl 3-acetoxy-2-methylene-3-(2-nitrophenyl)propanoate; With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; water; at 20 ℃; for 0.333333h;

ethyl acetoacetate; In tetrahydrofuran; water; at 20 ℃; for 0.5h;
DOI:10.1016/j.tet.2006.06.098

Reference yield:

: 159763-36-7
3-hydroxy-2-methylene-3-(2-nitrophenyl)propanoic acid methyl ester

: 910456-76-7
2-acetyl-4-methylene-3-(2-nitro-phenyl)-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / CH₂Cl₂ / 20 °C

2.1: DABCO / tetrahydrofuran; H₂O / 0.33 h / 20 °C

2.2: 85 percent / tetrahydrofuran; H₂O / 0.5 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2006.06.098

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 910456-76-7
2-acetyl-4-methylene-3-(2-nitro-phenyl)-pentanedioic acid 1-ethyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: DABCO / 20 °C

2.1: pyridine / CH₂Cl₂ / 20 °C

3.1: DABCO / tetrahydrofuran; H₂O / 0.33 h / 20 °C

3.2: 85 percent / tetrahydrofuran; H₂O / 0.5 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; dichloromethane; water; 1.1: Baylis-Hillman reaction;
DOI:10.1016/j.tet.2006.06.098