4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one

Base Information

Chemical Name:4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one
CAS No.:1443253-91-5
Molecular Formula:C₂₅H₂₀F₂N₆O₂
Molecular Weight:474.47
Hs Code.:

Synonyms:4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one

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Chemical Property of 4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one

Chemical Property:

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Technology Process of 4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one

There total 6 articles about 4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-pyridin-2-yl-piperazin-2-one dihydrochloride

: 1443257-71-3
(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl chloride

: 1443253-91-5
4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1443253-91-5
4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide; lithium hexamethyldisilazane / hexane / 2 h / 20 °C

3: potassium carbonate / [⁽²⁾H₆]acetone / 24 h / Reflux

4: lithium hydroxide / 1,4-dioxane; water / 24 h / 20 °C

5: thionyl chloride / 0.5 h / 60 °C

6: triethylamine / dichloromethane / 24 h / 20 °C

With thionyl chloride; potassium carbonate; triethylamine; sodium hydroxide; lithium hydroxide; lithium hexamethyldisilazane; In 1,4-dioxane; [⁽²⁾H₆]acetone; hexane; dichloromethane; water;

Reference yield:

: 2339-59-5
4-fluorobenzamidine

: 1443253-91-5
4-(2-(3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one

Guidance literature:: Multi-step reaction with 5 steps

2: potassium carbonate / [⁽²⁾H₆]acetone / 24 h / Reflux

3: lithium hydroxide / 1,4-dioxane; water / 24 h / 20 °C

4: thionyl chloride / 0.5 h / 60 °C

5: triethylamine / dichloromethane / 24 h / 20 °C

With thionyl chloride; potassium carbonate; triethylamine; lithium hydroxide; In 1,4-dioxane; [⁽²⁾H₆]acetone; dichloromethane; water;