(3S,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-tetradecahydro-cyclopenta[a]phenanthrene-7,12-dione

Base Information

Chemical Name:(3S,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-tetradecahydro-cyclopenta[a]phenanthrene-7,12-dione
CAS No.:223919-45-7
Molecular Formula:C₄₃H₅₂O₄
Molecular Weight:632.883
Hs Code.:

Synonyms:(3S,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-tetradecahydro-cyclopenta[a]phenanthrene-7,12-dione

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Chemical Property of (3S,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-tetradecahydro-cyclopenta[a]phenanthrene-7,12-dione

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Technology Process of (3S,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-tetradecahydro-cyclopenta[a]phenanthrene-7,12-dione

There total 2 articles about (3S,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-tetradecahydro-cyclopenta[a]phenanthrene-7,12-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 223919-44-6
Acetic acid (3S,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-7,12-dioxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

: 223919-45-7
(3S,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-tetradecahydro-cyclopenta[a]phenanthrene-7,12-dione

Guidance literature:: With sodium hydroxide; water; In tetrahydrofuran; methanol;
DOI:10.1016/S0040-4039(99)00076-3

Reference yield:

: Acetic acid (3S,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

: 223919-45-7
(3S,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-tetradecahydro-cyclopenta[a]phenanthrene-7,12-dione

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium dichromate, 4 Angstroem mol. sieves / CH₂Cl₂

2: 95 percent / NaOH, H₂O / tetrahydrofuran; methanol

With sodium hydroxide; dipyridinium dichromate; 4 A molecular sieve; water; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(99)00076-3

Reference yield:

: 223919-45-7
(3S,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-tetradecahydro-cyclopenta[a]phenanthrene-7,12-dione

: (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-Dimethyl-17-((R)-1-methyl-4-trityloxy-butyl)-hexadecahydro-cyclopenta[a]phenanthrene-3,7,12-triamine

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂

2: NaN₃ / dimethylsulfoxide

3: NH₂OH*HCl, AcONa / ethanol

4: NaBH₄, TiCl₄ / 1,2-dimethoxy-ethane

With sodium tetrahydroborate; sodium azide; hydroxylamine hydrochloride; sodium acetate; titanium tetrachloride; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(99)00076-3