1,1-dimethylethyl 4-{[(3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-3H-pyrazolo[3,4-c]isoquinolin-8-yl)oxy]methyl}piperidine-1-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-{[(3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-3H-pyrazolo[3,4-c]isoquinolin-8-yl)oxy]methyl}piperidine-1-carboxylate
CAS No.:838857-27-5
Molecular Formula:C₄₁H₄₉FN₄O₅
Molecular Weight:696.862
Hs Code.:

1,1-dimethylethyl 4-{[(3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-3H-pyrazolo[3,4-c]isoquinolin-8-yl)oxy]methyl}piperidine-1-carboxylate

Synonyms:1,1-dimethylethyl 4-{[(3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-3H-pyrazolo[3,4-c]isoquinolin-8-yl)oxy]methyl}piperidine-1-carboxylate

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Chemical Property of 1,1-dimethylethyl 4-{[(3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-3H-pyrazolo[3,4-c]isoquinolin-8-yl)oxy]methyl}piperidine-1-carboxylate

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Technology Process of 1,1-dimethylethyl 4-{[(3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-3H-pyrazolo[3,4-c]isoquinolin-8-yl)oxy]methyl}piperidine-1-carboxylate

There total 13 articles about 1,1-dimethylethyl 4-{[(3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-3H-pyrazolo[3,4-c]isoquinolin-8-yl)oxy]methyl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 838857-25-3
3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-3H-pyrazolo[3,4-c]isoquinolin-8-ol

: 161975-39-9
tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

: 838857-27-5
1,1-dimethylethyl 4-{[(3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-3H-pyrazolo[3,4-c]isoquinolin-8-yl)oxy]methyl}piperidine-1-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 1.5h;

Reference yield:

: 838857-04-8
(6-fluoro-2,2-dimethyl-4H-1,3-benzodioxin-8-yl)methanol

: 838857-27-5
1,1-dimethylethyl 4-{[(3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-3H-pyrazolo[3,4-c]isoquinolin-8-yl)oxy]methyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide / dichloromethane; <730 ml / 0.25 h / 0 °C

2.1: 3-chloro-benzenecarboperoxoic acid / 1,1-dichloroethane / 0.33 h / 70 °C

2.2: 0.33 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 1.75 h / 20 °C

4.1: hydrogenchloride; water / ethanol / 0.33 h / 85 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 0 °C

7.1: N,N-dimethyl-formamide / 2.33 h / 50 °C

8.1: sodium hydride / tetrahydrofuran / 0.25 h / 40 °C

9.1: ethanol / 16 h / 20 - 75 °C

10.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethyl acetate / 2 h / 2068.65 Torr

11.1: acetic acid / 120 °C

12.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 90 °C

With hydrogenchloride; sodium hypochlorite; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; hydrogen; sodium hydride; sodium hydrogencarbonate; caesium carbonate; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; potassium bromide; palladium 10% on activated carbon; In tetrahydrofuran; 1,1-dichloroethane; ethanol; dichloromethane; <730 ml; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 838857-05-9
6-fluoro-2,2-dimethyl-4H-1,3-benzodioxine-8-carbaldehyde

: 838857-27-5
1,1-dimethylethyl 4-{[(3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-3H-pyrazolo[3,4-c]isoquinolin-8-yl)oxy]methyl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 11 steps

1.1: 3-chloro-benzenecarboperoxoic acid / 1,1-dichloroethane / 0.33 h / 70 °C

1.2: 0.33 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 1.75 h / 20 °C

3.1: hydrogenchloride; water / ethanol / 0.33 h / 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 0 °C

6.1: N,N-dimethyl-formamide / 2.33 h / 50 °C

7.1: sodium hydride / tetrahydrofuran / 0.25 h / 40 °C

8.1: ethanol / 16 h / 20 - 75 °C

9.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethyl acetate / 2 h / 2068.65 Torr

10.1: acetic acid / 120 °C

11.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 90 °C

With hydrogenchloride; thionyl chloride; water; hydrogen; sodium hydride; caesium carbonate; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,1-dichloroethane; ethanol; ethyl acetate; N,N-dimethyl-formamide;