3-Amino-6-chloro-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide

Base Information

• Chemical Name: 3-Amino-6-chloro-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide
• CAS No.: 319002-53-4
• Molecular Formula: C₅H₄ClN₃O₂S₂
• Molecular Weight: 237.691
• Hs Code.: 2933990090
• Mol file: 319002-53-4.mol

Synonyms:3-Amino-6-chloro-4H-thieno[3,2-e]-1,2,4-thiadiazine1,1-dioxide

Chemical Property of 3-Amino-6-chloro-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide

Chemical Property:

• Melting Point: >350 °C (decomp)
• Boiling Point: 466.1±55.0 °C(Predicted)
• PKA: -7.20±0.20(Predicted)
• PSA: 121.17000
• Density: 2.23±0.1 g/cm3(Predicted)
• LogP: 2.18510

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-6-chloro-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide

There total 6 articles about 3-Amino-6-chloro-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3,6-dichloro-4H-thieno-[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (194086-61-8) → 3-amino-6-chloro-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (319002-53-4)

Guidance literature:

With ammonium hydroxide; at 100 ℃; for 16h;

DOI:10.1021/jm0208121

Reference yield: 89.0%

N-[(3-bromo-5-chlorothien-2-yl)sulfonyl]-N'-(1-methylcyclopropyl)guanidine (319002-85-2) → 3-amino-6-chloro-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (319002-53-4) + 6-chloro-3-(1-methylcyclopropyl)amino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (279215-43-9)

Guidance literature:

With copper; potassium carbonate; In 1-methyl-pyrrolidin-2-one; water; at 100 ℃; for 20h;

DOI:10.1021/jm060042j

Reference yield: 66.0%

N-[(3,5-dichlorothien-2-yl)sulfonyl]-N'-(1-methylcyclopropyl)guanidine (319002-86-3) → 3-amino-6-chloro-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (319002-53-4) + 6-chloro-3-(1-methylcyclopropyl)amino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide (279215-43-9)

Guidance literature:

With copper(I) oxide; caesium carbonate; In butan-1-ol; for 20h; Heating;

DOI:10.1021/jm060042j

upstream raw materials:

3,6-dichloro-4H-thieno-[3,2-e]-1,2,4-thiadiazine 1,1-dioxide

N-[(3,5-dichlorothien-2-yl)sulfonyl]-N'-(1-methylcyclopropyl)guanidine

N-[(3-bromo-5-chlorothien-2-yl)sulfonyl]-N'-(1-methylcyclopropyl)guanidine

6-chloro-2,3-dihydro-3-oxo-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide