8-[3-(N-Glycyl-N-methylamino)-2,6-dimethoxybenzyloxy]-2-methylquinoline

Base Information

Chemical Name:8-[3-(N-Glycyl-N-methylamino)-2,6-dimethoxybenzyloxy]-2-methylquinoline
CAS No.:179622-75-4
Molecular Formula:C₂₂H₂₅N₃O₄
Molecular Weight:395.458
Hs Code.:

Synonyms:8-[3-(N-Glycyl-N-methylamino)-2,6-dimethoxybenzyloxy]-2-methylquinoline

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Chemical Property of 8-[3-(N-Glycyl-N-methylamino)-2,6-dimethoxybenzyloxy]-2-methylquinoline

Chemical Property:

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Technology Process of 8-[3-(N-Glycyl-N-methylamino)-2,6-dimethoxybenzyloxy]-2-methylquinoline

There total 10 articles about 8-[3-(N-Glycyl-N-methylamino)-2,6-dimethoxybenzyloxy]-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.6%

: 213988-04-6
N-[2,4-Dimethoxy-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-methyl-acetamide

: 179622-75-4
8-[3-(N-Glycyl-N-methylamino)-2,6-dimethoxybenzyloxy]-2-methylquinoline

Guidance literature:: With hydrazine hydrate; In ethanol; for 1h; Heating;
DOI:10.1021/jm980330i

Reference yield:

: 179626-08-5
8-[3-amino-2,6-dimethoxybenzyloxy]-2-methylquinoline

: 179622-75-4
8-[3-(N-Glycyl-N-methylamino)-2,6-dimethoxybenzyloxy]-2-methylquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: DMAP, pyridine / 2 h / 50 °C

2: NaH / dimethylformamide / 4 h / 50 °C

3: H₂NNH₂*H₂O / CH₂Cl₂; ethanol / 2 h / Heating

With pyridine; dmap; sodium hydride; hydrazine hydrate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00736-7

Reference yield:

: 179626-07-4
8-[2,6-dimethoxy-3-nitrobenzyloxy]-2-methylquinoline

: 179622-75-4
8-[3-(N-Glycyl-N-methylamino)-2,6-dimethoxybenzyloxy]-2-methylquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: SnCl₂*2H₂O / diethyl ether / 1 h / Heating

2: DMAP, pyridine / 2 h / 50 °C

3: NaH / dimethylformamide / 4 h / 50 °C

4: H₂NNH₂*H₂O / CH₂Cl₂; ethanol / 2 h / Heating

With pyridine; dmap; sodium hydride; hydrazine hydrate; tin(ll) chloride; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00736-7