4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]trifluoroacetamido]benzoic acid

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Chemical Name:4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]trifluoroacetamido]benzoic acid
CAS No.:118271-03-7
Molecular Formula:C₁₆H₁₆F₃N₅O₄
Molecular Weight:399.329
Hs Code.:

Synonyms:4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]trifluoroacetamido]benzoic acid

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Chemical Property of 4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]trifluoroacetamido]benzoic acid

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Technology Process of 4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]trifluoroacetamido]benzoic acid

There total 5 articles about 4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]trifluoroacetamido]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 118271-02-6
4-<3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propylamino>benzoic acid one-half sodium salt

: 407-25-0
trifluoroacetic anhydride

: 118271-03-7
4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]trifluoroacetamido]benzoic acid

Guidance literature:: for 18h; Ambient temperature;
DOI:10.1002/jhet.5570270654

Reference yield:

: 118252-53-2
3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propionaldehyde

: 118271-03-7
4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]trifluoroacetamido]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) glacial acetic acid, 3 Angstroem molecular sieves 2.) sodium cyanoborohydride / 1.) MeOH, 3 h, r.t. 2.) 17 h

2: 71 percent / 1.0N NaOH / aq. ethanol / 20 h / 70 °C

3: 81 percent / 18 h / Ambient temperature

With sodium hydroxide; 3 A molecular sieve; sodium cyanoborohydride; acetic acid; In ethanol;
DOI:10.1002/jhet.5570270654

Reference yield:

: 118271-01-5
ethyl 4-<3-<2-(acetylamino)-4-(diacetylamino)-1,6-dihydro-6-oxo-5-pyrimidinyl>propylamino>benzoate

: 118271-03-7
4-[N-[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]trifluoroacetamido]benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / 1.0N NaOH / aq. ethanol / 20 h / 70 °C

2: 81 percent / 18 h / Ambient temperature

With sodium hydroxide; In ethanol;
DOI:10.1002/jhet.5570270654