N⁶-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate)

Base Information

Chemical Name:N⁶-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate)
CAS No.:691409-55-9
Molecular Formula:C₄₇H₄₅N₅O₉P₂
Molecular Weight:885.85
Hs Code.:

N<sup>6</sup>-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate)

Synonyms:N⁶-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate)

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Chemical Property of N⁶-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate)

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Technology Process of N⁶-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate)

There total 5 articles about N⁶-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 691409-52-6
N⁶-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine

: 990-91-0
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

: 691409-55-9
N⁶-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate)

Guidance literature:: N⁶-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine; With potassium tert-butylate; In tetrahydrofuran; at -40 ℃; for 0.0833333h;

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate; In tetrahydrofuran; at -40 ℃; for 0.5h;
DOI:10.1016/j.bmc.2003.12.041

Reference yield:

: 691409-46-8
2-iodo-N⁶-methyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine

: 691409-55-9
N⁶-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate)

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / Et₃N; (PPh₃)2PdCl₂; CuI / 3 h / 20 °C

2.1: 94 percent / TBAF / tetrahydrofuran; acetonitrile / 1 h / 20 °C

3.1: t-BuOK / tetrahydrofuran / 0.08 h / -40 °C

3.2: 95 percent / tetrahydrofuran / 0.5 h / -40 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; acetonitrile; 1.1: Sonogashira reaction;
DOI:10.1016/j.bmc.2003.12.041

Reference yield:

: 691409-49-1
N⁶-methyl-2-(2-phenylethynyl)-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine

: 691409-55-9
N⁶-methyl-2-(2-phenylethynyl)-2'-deoxyadenosine-3',5'-bis(dibenzylphosphate)

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / TBAF / tetrahydrofuran; acetonitrile / 1 h / 20 °C

2.1: t-BuOK / tetrahydrofuran / 0.08 h / -40 °C

2.2: 95 percent / tetrahydrofuran / 0.5 h / -40 °C

With potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bmc.2003.12.041