N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

Base Information

Chemical Name:N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide
CAS No.:1266584-06-8
Molecular Formula:C₂₇H₃₆ClN₇O
Molecular Weight:510.082
Hs Code.:

Synonyms:N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

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Chemical Property of N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

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Technology Process of N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

There total 8 articles about N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 109-01-3
1-methyl-piperazine

: 1266584-27-3
3-chloro-N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)propanamide

: 1266584-06-8
N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:: With potassium iodide; In ethanol; for 5h; Reflux;
DOI:10.1016/j.ejmech.2011.10.057

Reference yield:

: 1266584-22-8
N¹-(2-(4-chloro-2-nitrophenyl)quinazolin-4-yl)-N³,N³-dimethylpropane-1,3-diamine

: 1266584-06-8
N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrazine hydrate / isopropyl alcohol / 2 h / Reflux

2: potassium carbonate / dichloromethane / 0 - 20 °C

3: potassium iodide / ethanol / 5 h / Reflux

With palladium 10% on activated carbon; potassium carbonate; hydrazine hydrate; potassium iodide; In ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.ejmech.2011.10.057

Reference yield:

: 1266584-24-0
N¹-(2-(2-amino-4-chlorophenyl)quinazolin-4-yl)-N³,N³-dimethylpropane-1,3-diamine

: 1266584-06-8
N-(5-chloro-2-(4-(3-(dimethylamino)propylamino)quinazolin-2-yl)phenyl)-3-(4-methylpiperazin-1-yl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dichloromethane / 0 - 20 °C

2: potassium iodide / ethanol / 5 h / Reflux

With potassium carbonate; potassium iodide; In ethanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.10.057