Venlafaxine hydrochloride, (S)-

Base Information

Chemical Name:Venlafaxine hydrochloride, (S)-
CAS No.:93413-45-7
Molecular Formula:C₁₇H₂₇NO₂*ClH
Molecular Weight:313.868
Hs Code.:
UNII:720K1ZAR2W

Synonyms:Venlafaxine hydrochloride, (S)-;(S)-Venlafaxine hydrochloride;720K1ZAR2W;UNII-720K1ZAR2W;93413-45-7;Cyclohexanol, 1-((1S)-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, hydrochloride;Cyclohexanol, 1-((1S)-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, hydrochloride (1:1);Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, hydrochloride, (S)-;SCHEMBL4512264

Suppliers and Price of Venlafaxine hydrochloride, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Venlafaxine hydrochloride, (S)-

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:313.1808568
Heavy Atom Count:21
Complexity:279

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl
Isomeric SMILES:CN(C)C[C@H](C1=CC=C(C=C1)OC)C2(CCCCC2)O.Cl

Technology Process of Venlafaxine hydrochloride, (S)-

There total 5 articles about Venlafaxine hydrochloride, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 111-24-0
1,5-dibromo-pentane

: 909398-05-6
methyl 3-N,N-dimethylamino-(2S)-(4-methoxyphenyl)propionate

: 93413-45-7
(+)-Venlafaxine hydrochloride

Guidance literature:: 1,5-dibromo-pentane; With magnesium; In diethyl ether; for 3h; Reflux;

methyl 3-N,N-dimethylamino-(2S)-(4-methoxyphenyl)propionate; In diethyl ether; at 0 - 25 ℃;

With hydrogenchloride; In diethyl ether; water;
DOI:10.1002/anie.202016220

Reference yield:

: 93413-46-8,93413-69-5,131801-71-3,93413-44-6
(S)-1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol

: 93413-45-7
(+)-Venlafaxine hydrochloride

Guidance literature:: With hydrogenchloride; In methanol;

Reference yield:

: 99300-78-4
venlafaxine hydrochloride

: 93413-45-7
(+)-Venlafaxine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / water

2.1: tetrahydrofuran / 0.5 h / Resolution of racemate; Reflux

2.2: 0.5 h / Resolution of racemate; Reflux

3.1: sodium hydroxide / water

4.1: hydrogenchloride / ethyl acetate

With hydrogenchloride; sodium hydroxide; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1002/chir.22790