ethyl (Z)-3-(2-acetamido-2-oxo-1-(trityloxyimino)ethyl)-1,2,4-thiadiazol-5-ylcarbamate

Base Information

Chemical Name:ethyl (Z)-3-(2-acetamido-2-oxo-1-(trityloxyimino)ethyl)-1,2,4-thiadiazol-5-ylcarbamate
CAS No.:1283593-50-9
Molecular Formula:C₂₈H₂₅N₅O₅S
Molecular Weight:543.603
Hs Code.:

Synonyms:ethyl (Z)-3-(2-acetamido-2-oxo-1-(trityloxyimino)ethyl)-1,2,4-thiadiazol-5-ylcarbamate

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Chemical Property of ethyl (Z)-3-(2-acetamido-2-oxo-1-(trityloxyimino)ethyl)-1,2,4-thiadiazol-5-ylcarbamate

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Technology Process of ethyl (Z)-3-(2-acetamido-2-oxo-1-(trityloxyimino)ethyl)-1,2,4-thiadiazol-5-ylcarbamate

There total 2 articles about ethyl (Z)-3-(2-acetamido-2-oxo-1-(trityloxyimino)ethyl)-1,2,4-thiadiazol-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1245649-23-3
ethyl 3-(2-acetamido-2-oxoethyl)-1,2,4-thiadiazol-5-ylcarbamate

: 76-83-5
trityl chloride

: 1283593-51-0
ethyl (E)-3-(2-acetamido-2-oxo-1-(trityloxyimino)ethyl)-1,2,4-thiadiazol-5-ylcarbamate

: 1283593-50-9
ethyl (Z)-3-(2-acetamido-2-oxo-1-(trityloxyimino)ethyl)-1,2,4-thiadiazol-5-ylcarbamate

Guidance literature:: ethyl 3-(2-acetamido-2-oxoethyl)-1,2,4-thiadiazol-5-ylcarbamate; With hydrogenchloride; i-propyl nitrite; In tetrahydrofuran; water; at 0 ℃; for 4.5h;

trityl chloride; With triethylamine; In tetrahydrofuran; water; at 0 ℃; for 2h; pH=10;
DOI:10.1021/op100323b

Reference yield:

: 4264-08-8
N-(3-aminoisoxazol-5-yl)acetamide

: 1283593-51-0
ethyl (E)-3-(2-acetamido-2-oxo-1-(trityloxyimino)ethyl)-1,2,4-thiadiazol-5-ylcarbamate

: 1283593-50-9
ethyl (Z)-3-(2-acetamido-2-oxo-1-(trityloxyimino)ethyl)-1,2,4-thiadiazol-5-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / 5 h / 5 - 20 °C

1.2: 3 h / 25 °C

2.1: hydrogenchloride; i-propyl nitrite / tetrahydrofuran; water / 4.5 h / 0 °C

2.2: 2 h / 0 °C / pH 10

With hydrogenchloride; i-propyl nitrite; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/op100323b