Cyclopropane, 1-chloro-2-[(3E)-4-chloro-3-buten-1-ynyl]-, (1R,2S)- (9CI)

Base Information

Chemical Name:Cyclopropane, 1-chloro-2-[(3E)-4-chloro-3-buten-1-ynyl]-, (1R,2S)- (9CI)
CAS No.:316377-63-6
Molecular Formula:C₇H₆Cl₂
Molecular Weight:161.031
Hs Code.:
Mol file:316377-63-6.mol

Synonyms:Cyclopropane,1-chloro-2-[(3E)-4-chloro-3-buten-1-ynyl]-, (1R,2S)- (9CI)

Suppliers and Price of Cyclopropane, 1-chloro-2-[(3E)-4-chloro-3-buten-1-ynyl]-, (1R,2S)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclopropane, 1-chloro-2-[(3E)-4-chloro-3-buten-1-ynyl]-, (1R,2S)- (9CI)

Chemical Property:

PSA：0.00000
LogP:2.36960

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of Cyclopropane, 1-chloro-2-[(3E)-4-chloro-3-buten-1-ynyl]-, (1R,2S)- (9CI)

There total 2 articles about Cyclopropane, 1-chloro-2-[(3E)-4-chloro-3-buten-1-ynyl]-, (1R,2S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 156-60-5,43695-79-0
trans-1,2-dichloroethylene

: 316377-61-4
trans-2-chlorocyclopropylacetylene

: 316377-63-6
(E)-chloro-4-(trans-2-chlorocyclopropyl)-but-3-ynene

Guidance literature:: With piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;
DOI:10.1021/ol006696i

Reference yield:

: 316377-60-3
trans-2-chloro-1-(2,2'-dibromoethynyl)-cyclopropane

: 316377-63-6
(E)-chloro-4-(trans-2-chlorocyclopropyl)-but-3-ynene

Guidance literature:: Multi-step reaction with 2 steps

1: MeLi / diethyl ether / -78 °C

2: 37 percent / CuI; piperidine / Pd(PPh₃)4 / tetrahydrofuran

With piperidine; copper(l) iodide; methyllithium; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; 1: Elimination / 2: Sonogashira coupling;
DOI:10.1021/ol006696i