Dimethylcarbamoylmethyl-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester

Base Information

Chemical Name:Dimethylcarbamoylmethyl-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester
CAS No.:689248-35-9
Molecular Formula:C₁₈H₂₆N₂O₄
Molecular Weight:334.415
Hs Code.:

Synonyms:Dimethylcarbamoylmethyl-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester

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Chemical Property of Dimethylcarbamoylmethyl-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester

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Technology Process of Dimethylcarbamoylmethyl-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester

There total 2 articles about Dimethylcarbamoylmethyl-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: N,N-dimethyl-2-(6-methyl-tetrahydro-pyran-2-ylamino)-acetamide

: Dimethylcarbamoylmethyl-((2S,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester

: 689248-35-9
Dimethylcarbamoylmethyl-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester

Guidance literature:: With sodium carbonate; In diethyl ether; water; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.tetasy.2004.01.026

Reference yield:

: 194795-88-5
(6R)-6-methyltetrahydropyran-2-ol

: 689248-35-9
Dimethylcarbamoylmethyl-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 16 h / 20 °C

2: 71 percent / Na₂CO₃ / diethyl ether; H₂O / 3 h / 0 - 20 °C

With sodium carbonate; In diethyl ether; water;
DOI:10.1016/j.tetasy.2004.01.026

Reference yield: 80.0%

: 939-26-4
2-bromomethylnaphthyl bromide

: 689248-35-9
Dimethylcarbamoylmethyl-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester

: (1-Dimethylcarbamoyl-2-naphthalen-2-yl-ethyl)-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester

Guidance literature:: Dimethylcarbamoylmethyl-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

2-bromomethylnaphthyl bromide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.tetasy.2004.01.026