N-((2S,3R)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-((2S,3R)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide
CAS No.:1268832-88-7
Molecular Formula:C₃₉H₄₄NO₃PSSi
Molecular Weight:665.909
Hs Code.:

Synonyms:N-((2S,3R)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2S,3R)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

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Technology Process of N-((2S,3R)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

There total 4 articles about N-((2S,3R)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1268832-86-5
N-((2S,3R)-1-(diphenylphosphino)-3-hydroxybutan-2-yl)-4-methylbenzenesulfonamide

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1268832-88-7
N-((2S,3R)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 28h; Inert atmosphere;
DOI:10.1021/ol103145g

Reference yield:

: 1268832-84-3
(R)-2-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-1-tosylaziridine

: 1268832-88-7
N-((2S,3R)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; 1,4-dioxane / 1 h / 0 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 28 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; 1,4-dioxane; mineral oil;
DOI:10.1021/ol103145g

Reference yield:

: 220306-97-8
N-[(1R,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxymethyl-propyl]-4-methyl-benzenesulfonamide

: 1268832-88-7
N-((2S,3R)-3-(tert-butyldiphenylsilyloxy)-1-(diphenylphosphino)butan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: methanesulfonyl chloride; triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran; 1,4-dioxane / 1 h / 0 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

4: sodium hydride / tetrahydrofuran; mineral oil / 28 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; sodium hydride; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; mineral oil;
DOI:10.1021/ol103145g