2--N-(3-bromo-propionyl)glycine Benzyl Ester

Base Information

• Chemical Name: 2--N-(3-bromo-propionyl)glycine Benzyl Ester
• CAS No.: 70875-44-4
• Molecular Formula: C₂₅H₂₄BrNO₄
• Molecular Weight: 482.374
• Mol file: 70875-44-4.mol

Synonyms:2--N-(3-bromo-propionyl)glycine Benzyl Ester

Chemical Property of 2--N-(3-bromo-propionyl)glycine Benzyl Ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2--N-(3-bromo-propionyl)glycine Benzyl Ester

There total 1 articles about 2--N-(3-bromo-propionyl)glycine Benzyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Amino-(4-benzyloxy-phenyl)-acetic acid benzyl ester (70875-52-4) + 3-Bromopropionyl chloride (15486-96-1) → 2--N-(3-bromo-propionyl)glycine Benzyl Ester (70875-44-4)

Guidance literature:

With pyridine; In dichloromethane; 1.) 0 deg C, 2.) room temp., 12h;

DOI:10.1021/jo00328a002

Reference yield: 46.0%

2--N-(3-bromo-propionyl)glycine Benzyl Ester (70875-44-4) → Benzyl α--2-oxo-1-azetidineacetate (70875-49-9)

Guidance literature:

With sodium hydride; In dichloromethane; N,N-dimethyl-formamide; for 2h; Ambient temperature;

DOI:10.1021/jo00328a002

Reference yield:

2--N-(3-bromo-propionyl)glycine Benzyl Ester (70875-44-4) → (+/-) nocardicinic acid (77698-53-4,59831-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / NaH / dimethylformamide; CH₂Cl₂ / 2 h / Ambient temperature

2: 98 percent / H₂ / 10percent Pd on charcoal / ethanol; H₂O / 14 h / 2585.7 Torr

With hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jo00328a002

upstream raw materials:

Amino-(4-benzyloxy-phenyl)-acetic acid benzyl ester

3-Bromopropionyl chloride

Downstream raw materials:

Benzyl α--2-oxo-1-azetidineacetate

(+/-) nocardicinic acid

(+/-) ethyl nocardicinate