Technology Process of (6Z,8E,10E,14Z)-(5S,12R)-5-Benzoyloxy-12-hydroxy-icosa-6,8,10,14-tetraenedioic acid 1-ethyl ester 20-methyl ester
There total 10 articles about (6Z,8E,10E,14Z)-(5S,12R)-5-Benzoyloxy-12-hydroxy-icosa-6,8,10,14-tetraenedioic acid 1-ethyl ester 20-methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 60 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C
3: TFA / tetrahydrofuran; H2O / 6 h / Ambient temperature
4: Pb(OAc)4, Na2CO3
5: 30 percent / benzene / 16 h / 80 °C
6: 80 percent / NaBH4, CeCl3 / propan-2-ol / 0 °C
7: 40 percent / 1) CBr4; / 2) CH3CN
8: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C
9: -78 - -45 °C
10: 80 percent / (nBu)4NF / tetrahydrofuran / 0 - 25 °C
With
lead(IV) acetate; sodium tetrahydroborate; cerium(III) chloride; carbon tetrabromide; tetrabutyl ammonium fluoride; sodium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; water; isopropyl alcohol; benzene;
DOI:10.1016/S0040-4039(00)85704-4
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 30 percent / benzene / 16 h / 80 °C
2: 80 percent / NaBH4, CeCl3 / propan-2-ol / 0 °C
3: 40 percent / 1) CBr4; / 2) CH3CN
4: LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C
5: -78 - -45 °C
6: 80 percent / (nBu)4NF / tetrahydrofuran / 0 - 25 °C
With
sodium tetrahydroborate; cerium(III) chloride; carbon tetrabromide; tetrabutyl ammonium fluoride; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; isopropyl alcohol; benzene;
DOI:10.1016/S0040-4039(00)85704-4
