isopropyl N-phenyl difluoromethylphosphonamidate

Base Information

• Chemical Name: isopropyl N-phenyl difluoromethylphosphonamidate
• CAS No.: 1314353-32-6
• Molecular Formula: C₁₀H₁₄F₂NO₂P
• Molecular Weight: 249.197
• Mol file: 1314353-32-6.mol

Synonyms:isopropyl N-phenyl difluoromethylphosphonamidate

Chemical Property of isopropyl N-phenyl difluoromethylphosphonamidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of isopropyl N-phenyl difluoromethylphosphonamidate

There total 1 articles about isopropyl N-phenyl difluoromethylphosphonamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

aniline (62-53-3) + diisopropyl (methylsulfanyl)difluoromethylphosphonate (327156-97-8) → isopropyl N-phenyl difluoromethylphosphonamidate (1314353-32-6)

Guidance literature:

diisopropyl (methylsulfanyl)difluoromethylphosphonate; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.25h;

aniline; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

With ammonium chloride; In tetrahydrofuran; water; at -78 ℃;

DOI:10.1016/j.tetlet.2011.05.034

Reference yield:

isopropyl N-phenyl difluoromethylphosphonamidate (1314353-32-6) → C10H14F2NO2P*ClH

Guidance literature:

With hydrogenchloride; In methanol; water; pH=0.3;

DOI:10.1016/j.tetlet.2011.05.034

Reference yield:

methanesulfonic acid (75-75-2,98527-29-8) + isopropyl N-phenyl difluoromethylphosphonamidate (1314353-32-6) → CH4O3S*C10H14F2NO2P (1314353-34-8)

Guidance literature:

In chloroform-d1; at 20 ℃;

DOI:10.1016/j.tetlet.2011.05.034

upstream raw materials:

aniline

diisopropyl (methylsulfanyl)difluoromethylphosphonate

Downstream raw materials:

CH₄O₃S*C₁₀H₁₄F₂NO₂P