1-(2,6-Dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine

Base Information

Chemical Name:1-(2,6-Dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine
CAS No.:315203-39-5
Molecular Formula:C19H20 Cl2 N4
Molecular Weight:375.301
Hs Code.:2933990090
DSSTox Substance ID:DTXSID90440911
Wikidata:Q82257407
Mol file:315203-39-5.mol

Synonyms:315203-39-5;1-(2,6-Dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine;1-[(2,6-dichlorophenyl)methyl]-3-(pyrrolidin-1-ylmethyl)indazol-6-amine;1-(2,6-DICHLORO-BENZYL)-3-PYRROLIDIN-1-YLMETHYL-1H-INDAZOL-6-YLAMINE;1-[(2,6-Dichlorophenyl)methyl]-3-[(pyrrolidin-1-yl)methyl]-1H-indazol-6-amine;1-[(2,6-Dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)- 1H-indazol-6-amine;C19H20Cl2N4;SCHEMBL14090270;DTXSID90440911;MFCD03093364;1H-Indazol-6-amine,1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-;AKOS024464548;DS-7836;CS-0186216;A875880

Suppliers and Price of 1-(2,6-Dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-(2,6-Dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine 95+%
100mg
$ 83.00

Crysdot
1-(2,6-Dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine 95+%
250mg
$ 133.00

Crysdot
1-(2,6-Dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine 95+%
1g
$ 333.00

Chemenu
1-(2,6-dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine 95%
1g
$ 315.00

Biosynth Carbosynth
1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indazol-6-amine
250 mg
$ 210.00

Biosynth Carbosynth
1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indazol-6-amine
100 mg
$ 167.00

Biosynth Carbosynth
1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indazol-6-amine
50 mg
$ 104.50

Biosynth Carbosynth
1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indazol-6-amine
500 mg
$ 335.00

Biosynth Carbosynth
1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indazol-6-amine
1 g
$ 535.90

American Custom Chemicals Corporation
1-(2,6-DICHLORO-BENZYL)-3-PYRROLIDIN-1-YLMETHYL-1H-INDAZOL-6-YLAMINE 95.00%
5MG
$ 503.68

Total 11 raw suppliers

Chemical Property of 1-(2,6-Dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine

Chemical Property:

Boiling Point:555.1±50.0 °C(Predicted)
PKA:8.80±0.20(Predicted)
PSA：47.08000
Density:1.41±0.1 g/cm3(Predicted)
LogP:5.08850
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:374.1065020
Heavy Atom Count:25
Complexity:435

Purity/Quality:

97% ^*data from raw suppliers

1-(2,6-Dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)CC2=NN(C3=C2C=CC(=C3)N)CC4=C(C=CC=C4Cl)Cl

Technology Process of 1-(2,6-Dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine

There total 2 articles about 1-(2,6-Dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazol-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 372963-38-7
1-(2,6-dichlorobenzyl)-6-nitro-3-(pyrrolidin-1-ylmethyl)-1H-indazole

: 315203-39-5
1-(2,6-dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazole-6-amine

Guidance literature:: With iron(III) chloride hexahydrate; pyrographite; hydrazine hydrate; In methanol; at 100 ℃; for 2h; Sealed tube;
DOI:10.1016/j.bmc.2018.04.016

Reference yield:

: 315203-38-4
6-nitro-3-(pyrrolidin-1-ylmethyl)-1H-indazole

: 315203-39-5
1-(2,6-dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazole-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.4 g / KOH / tetrahydrofuran / 1 h / 20 °C

2: 1.75 g / ferric chloride hexahydrate; activated charcoal; 1,1-dimethylhydrazine / methanol / 2 h / Heating

With potassium hydroxide; iron(III) chloride; pyrographite; N,N-Dimethylhydrazine; In tetrahydrofuran; methanol;
DOI:10.1021/jm000506s

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 315203-39-5
1-(2,6-dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazole-6-amine

: 315203-40-8
tert-butyl ((S)-3-((S)-2-amino-3-(3,4-difluorophenyl)propanamido)-4-(benzylamino)-4-oxobutyl)carbamate

: {3-benzylcarbamoyl-3-[2-{3-[1-(2,6-dichloro-benzyl)-3-pyrrolidin-1-ylmethyl-1H-indazol-6-yl]-ureido}-3-(3,4-difluoro-phenyl)-propionylamino]-propyl}-carbamic acid tert-butyl ester

Guidance literature:: bis(trichloromethyl) carbonate; 1-(2,6-dichlorobenzyl)-3-(pyrrolidin-1-ylmethyl)-1H-indazole-6-amine; With dmap; In tetrahydrofuran; at -5 ℃; for 0.133333h; Sealed tube; Inert atmosphere;

tert-butyl ((S)-3-((S)-2-amino-3-(3,4-difluorophenyl)propanamido)-4-(benzylamino)-4-oxobutyl)carbamate; In tetrahydrofuran; at -5 - 20 ℃; for 2h; Sealed tube; Inert atmosphere;
DOI:10.1016/j.bmc.2018.04.016