6-NITRO INDAZOLE-3-CARBOXALDEHYDE

Base Information

• Chemical Name: 6-NITRO INDAZOLE-3-CARBOXALDEHYDE
• CAS No.: 315203-37-3
• Molecular Formula: C8H5N3O3
• Molecular Weight: 191.146
• Hs Code.: 2933990090
• Mol file: 315203-37-3.mol

Synonyms:6-NITRO INDAZOLE-3-CARBOXALDEHYDE;6-NITRO-1H-INDAZOLE-3-CARBALDEHYDE;6-NITRO-1H-INDAZOLE-3-CARBOXALDEHYDE;6-Nitro-1H-indazole-3-carboxyaldehyde;6-NITRO-3-CARBOXALDEHYDE;1H-Indazole-3-carboxaldehyde, 6-nitro-

Chemical Property of 6-NITRO INDAZOLE-3-CARBOXALDEHYDE

Chemical Property:

• Vapor Pressure: 8.37E-13mmHg at 25°C
• Refractive Index: 1.779
• Boiling Point: 463.463 °C at 760 mmHg
• Flash Point: 234.094 °C
• PSA: 91.57000
• Density: 1.612 g/cm³
• LogP: 1.80680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Nitro-1H-indazole-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-NITRO INDAZOLE-3-CARBOXALDEHYDE

There total 3 articles about 6-NITRO INDAZOLE-3-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.3%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 6-nitroindazole (7597-18-4) → 6-nitro-1H-indazole-3-carboxaldehyde (315203-37-3)

Guidance literature:

With trichlorophosphate; at 60 - 102 ℃; for 5h;

Reference yield: 77.0%

6-nitroindole (4769-96-4) → 6-nitro-1H-indazole-3-carboxaldehyde (315203-37-3)

Guidance literature:

6-nitroindole; With sodium nitrite; In water; at 20 ℃;

With hydrogenchloride; In water; at 20 ℃; for 1.5h;

DOI:10.1016/j.bmc.2018.04.016

Reference yield:

6-nitroindazole (7597-18-4) → 6-nitro-1H-indazole-3-carboxaldehyde (315203-37-3)

Guidance literature:

upstream raw materials:

6-nitroindole

6-nitroindazole

N,N-dimethyl-formamide

Downstream raw materials:

(Ε)-6-nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

(Ε)-6-amino-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

3-methyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-amine

3-methyl-1H-indazol-6-amine

Refernces

• 1、 Gandhi, Disha M.,Majewski, Mark W.,Rosas, Ricardo,Kentala, Kaitlin,Foster, Trevor J.,Greve, Eric,Dockendorff, Chris. "Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells". . p. 2514 - 2529. Retrieved 2018/04/30.
• 2、 -. "BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS". Page/Page column 60-61. . Retrieved 2010/11/28.