Pyridine, 5-(chloromethyl)-2-fluoro- (9CI)

Base Information

• Chemical Name: Pyridine, 5-(chloromethyl)-2-fluoro- (9CI)
• CAS No.: 315180-15-5
• Molecular Formula: C6H5 Cl F N
• Molecular Weight: 145.564
• Hs Code.: 2933399090
• Mol file: 315180-15-5.mol

Synonyms:5-Chloromethyl-2-fluoropyridine

Chemical Property of Pyridine, 5-(chloromethyl)-2-fluoro- (9CI)

Chemical Property:

• Vapor Pressure: 0.119mmHg at 25°C
• Refractive Index: 1.507
• Boiling Point: 227.048°C at 760 mmHg
• PKA: -1.20±0.10(Predicted)
• Flash Point: 91.116°C
• PSA: 12.89000
• Density: 1.271g/cm³
• LogP: 1.95950
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

5-(Chloromethyl)-2-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-(Chloromethyl)-2-fluoropyridine is a derivative of Pyridine (P991280), a basic six-membered heterocyclic ring. Pyridine is a base structure present in many biologically active compounds like the vitamins niacin and pyridoxal.

Technology Process of Pyridine, 5-(chloromethyl)-2-fluoro- (9CI)

There total 3 articles about Pyridine, 5-(chloromethyl)-2-fluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-fluoro-5-methylpyridine (2369-19-9) → 5-(dichloromethyl)-2-fluoropyridine + 2-fluoro-5-pyridylmethyl chloride (315180-15-5)

Guidance literature:

With hydrogenchloride; N-chloro-succinimide; dibenzoyl peroxide; In acetic acid; acetonitrile; Heating;

DOI:10.1021/jo9804339

Reference yield: 46.9%

2-fluoro-5-methylpyridine (2369-19-9) → 2-fluoro-5-pyridylmethyl chloride (315180-15-5)

Guidance literature:

With N-chloro-succinimide; acetic acid; dibenzoyl peroxide; In acetonitrile; for 5h; Inert atmosphere; Reflux;

Reference yield:

→ 2-fluoro-5-pyridylmethyl chloride (315180-15-5)

Guidance literature:

upstream raw materials:

2-fluoro-5-methylpyridine

Downstream raw materials:

(6-fluoropyridin-3-yl)methanol