(1R,2S)-2-(tert-butyldiphenylsilyloxymethyl)-3-(4-bromo-benzylidene)-cyclopentanol

Base Information

• Chemical Name: (1R,2S)-2-(tert-butyldiphenylsilyloxymethyl)-3-(4-bromo-benzylidene)-cyclopentanol
• CAS No.: 1242773-32-5
• Molecular Formula: C₂₉H₃₃BrO₂Si
• Molecular Weight: 521.569
• Mol file: 1242773-32-5.mol

Synonyms:(1R,2S)-2-(tert-butyldiphenylsilyloxymethyl)-3-(4-bromo-benzylidene)-cyclopentanol

Chemical Property of (1R,2S)-2-(tert-butyldiphenylsilyloxymethyl)-3-(4-bromo-benzylidene)-cyclopentanol

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (1R,2S)-2-(tert-butyldiphenylsilyloxymethyl)-3-(4-bromo-benzylidene)-cyclopentanol

There total 1 articles about (1R,2S)-2-(tert-butyldiphenylsilyloxymethyl)-3-(4-bromo-benzylidene)-cyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,3R)-1-(tert-butyldiphenylsilyl)oxy-7-(4-bromophenyl)-2,3-epoxy-hept-6-yne (1242773-17-6) → (1R,2S)-2-(tert-butyldiphenylsilyloxymethyl)-3-(4-bromo-benzylidene)-cyclopentanol (1242773-32-5) + 1-(tert-butyldiphenylsilyloxy)-7-(4-bromophenyl)-hept-6-yn-2-ol

Guidance literature:

With manganese; cyclohexa-1,4-diene; C₂₀H₂₈Cl₂Ti; 2,4,6-collidine hydrochloride; In tetrahydrofuran; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1021/ja105023y

Reference yield: 97.0%

(1R,2S)-2-(tert-butyldiphenylsilyloxymethyl)-3-(4-bromo-benzylidene)-cyclopentanol (1242773-32-5) → (1R,2S,3S)-2-(tert-butyldiphenylsilyloxymethyl)-3-(4-bromo-benzyl)-cyclopentanol (1242773-37-0)

Guidance literature:

With Crabtree's catalyst; hydrogen; In dichloromethane; at 20 ℃; for 12h; under 760.051 Torr;

DOI:10.1021/ja105023y

upstream raw materials:

(2S,3R)-1-(tert-butyldiphenylsilyl)oxy-7-(4-bromophenyl)-2,3-epoxy-hept-6-yne

Downstream raw materials:

(1R,2S,3S)-2-(tert-butyldiphenylsilyloxymethyl)-3-(4-bromo-benzyl)-cyclopentanol