1-[2-(4-fluorophenoxy)-2-phenyl-ethyl]-4-(2-methoxyphenyl)-piperazine

Base Information

• Chemical Name: 1-[2-(4-fluorophenoxy)-2-phenyl-ethyl]-4-(2-methoxyphenyl)-piperazine
• CAS No.: 691872-58-9
• Molecular Formula: C₂₅H₂₇FN₂O₂
• Molecular Weight: 406.5
• Mol file: 691872-58-9.mol

Synonyms:1-[2-(4-fluorophenoxy)-2-phenyl-ethyl]-4-(2-methoxyphenyl)-piperazine

Chemical Property of 1-[2-(4-fluorophenoxy)-2-phenyl-ethyl]-4-(2-methoxyphenyl)-piperazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[2-(4-fluorophenoxy)-2-phenyl-ethyl]-4-(2-methoxyphenyl)-piperazine

There total 5 articles about 1-[2-(4-fluorophenoxy)-2-phenyl-ethyl]-4-(2-methoxyphenyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

2-(4-fluorophenoxy)-2-phenyl-ethyl bromide (691872-55-6) + 1-(2-Methoxyphenyl)piperazine (35386-24-4) → 1-[2-(4-fluorophenoxy)-2-phenyl-ethyl]-4-(2-methoxyphenyl)-piperazine (691872-58-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 16h; Heating;

DOI:10.1016/j.bmc.2003.12.021

Reference yield:

2-(4-fluorophenoxy)-2-phenyl-ethylamine (691872-54-5) → 1-[2-(4-fluorophenoxy)-2-phenyl-ethyl]-4-(2-methoxyphenyl)-piperazine (691872-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 33 percent / TiBr₄; t-butyl nitrite / dimethylformamide / 1 h / 25 °C

2: 34 percent / K₂CO₃ / dimethylformamide / 16 h / Heating

With tert.-butylnitrite; titanium(IV) bromide; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2003.12.021

Reference yield:

[2-(4-fluorophenoxy)-2-phenylethyl]-carbamic acid tert-butyl ester (691872-53-4) → 1-[2-(4-fluorophenoxy)-2-phenyl-ethyl]-4-(2-methoxyphenyl)-piperazine (691872-58-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / hydrochloric acid / dioxane / 1.5 h / 25 °C

2: 33 percent / TiBr₄; t-butyl nitrite / dimethylformamide / 1 h / 25 °C

3: 34 percent / K₂CO₃ / dimethylformamide / 16 h / Heating

With hydrogenchloride; tert.-butylnitrite; titanium(IV) bromide; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2003.12.021

upstream raw materials:

2-(4-fluorophenoxy)-2-phenyl-ethyl bromide

1-(2-Methoxyphenyl)piperazine

2-(4-fluorophenoxy)-2-phenyl-ethylamine

[2-(4-fluorophenoxy)-2-phenylethyl]-carbamic acid tert-butyl ester