N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinamide

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Chemical Name:N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinamide
CAS No.:1351764-52-7
Molecular Formula:C₂₉H₂₃Cl₂FN₆O₄
Molecular Weight:609.444
Hs Code.:

Synonyms:N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinamide

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Chemical Property of N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinamide

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Technology Process of N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinamide

There total 13 articles about N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1271523-47-7
3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one

: 1351763-56-8
5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinic acid

: 1351764-52-7
N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinamide

Guidance literature:: 5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinic acid; With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; for 0.5h;

3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 591-35-5
3,5-dichlorophenol

: 1351764-52-7
N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / toluene; mineral oil / 2.25 h / 0 - 10 °C / Industry scale; Inert atmosphere

1.2: 2 h / 10 °C

2.1: potassium carbonate; sodium hydroxide / N,N-dimethyl-formamide; ethanol / 50 °C / Industry scale; Inert atmosphere

2.2: 1 h / 50 - 55 °C

3.1: triethylamine / palladium diacetate; CataCXiumPOMeCy / 1,4-dioxane / 1 h / 10 °C / Inert atmosphere; Industry scale

3.2: 5 h / 80 °C / Inert atmosphere

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

5.1: aluminum (III) chloride / methoxybenzene / 16 h / 70 °C / Inert atmosphere

6.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h

6.2: 20 °C

With 4-methyl-morpholine; aluminum (III) chloride; sodium hydride; sodium carbonate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; CataCXiumPOMeCy; palladium diacetate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; methoxybenzene; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1028332-19-5
3,5-dichloro-2-iodophenol

: 1351764-52-7
N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; sodium hydroxide / N,N-dimethyl-formamide; ethanol / 50 °C / Industry scale; Inert atmosphere

1.2: 1 h / 50 - 55 °C

2.1: triethylamine / palladium diacetate; CataCXiumPOMeCy / 1,4-dioxane / 1 h / 10 °C / Inert atmosphere; Industry scale

2.2: 5 h / 80 °C / Inert atmosphere

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

4.1: aluminum (III) chloride / methoxybenzene / 16 h / 70 °C / Inert atmosphere

5.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h

5.2: 20 °C

With 4-methyl-morpholine; aluminum (III) chloride; sodium carbonate; potassium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; CataCXiumPOMeCy; palladium diacetate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; methoxybenzene; N,N-dimethyl-formamide;