(3S,5S)-3,5-dihydroxy-6-(trityloxy)hexanenitrile

Base Information

Chemical Name:(3S,5S)-3,5-dihydroxy-6-(trityloxy)hexanenitrile
CAS No.:1364244-34-7
Molecular Formula:C₂₅H₂₅NO₃
Molecular Weight:387.478
Hs Code.:

Synonyms:(3S,5S)-3,5-dihydroxy-6-(trityloxy)hexanenitrile

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Chemical Property of (3S,5S)-3,5-dihydroxy-6-(trityloxy)hexanenitrile

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Technology Process of (3S,5S)-3,5-dihydroxy-6-(trityloxy)hexanenitrile

There total 8 articles about (3S,5S)-3,5-dihydroxy-6-(trityloxy)hexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76-83-5
trityl chloride

: 1364244-34-7
(3S,5S)-3,5-dihydroxy-6-(trityloxy)hexanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 16 h / 0 - 20 °C / Inert atmosphere

1.2: 5 h / -10 - -5 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2585.81 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: Cooling

4.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / -10 °C / Inert atmosphere

4.2: Cooling

5.1: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

6.1: sodium methylate / 1,4-dioxane; methanol / 3 h / -10 °C

7.1: 1,2-dimethoxyethane; water; tetrahydrofuran / 50 h / 20 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; sodium methylate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 2782-09-4
D-arabinono-1,4-lactone

: 1364244-34-7
(3S,5S)-3,5-dihydroxy-6-(trityloxy)hexanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 16 h / 0 - 20 °C / Inert atmosphere

1.2: 5 h / -10 - -5 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2585.81 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: Cooling

4.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / -10 °C / Inert atmosphere

4.2: Cooling

5.1: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

6.1: sodium methylate / 1,4-dioxane; methanol / 3 h / -10 °C

7.1: 1,2-dimethoxyethane; water; tetrahydrofuran / 50 h / 20 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; sodium methylate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1364244-19-8
5-O-(triphenylmethyl)-D-arabinono-1,4-lactone

: 1364244-34-7
(3S,5S)-3,5-dihydroxy-6-(trityloxy)hexanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 5 h / -10 °C / Inert atmosphere

2.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2585.81 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: Cooling

4.1: sodium tetrahydroborate / tetrahydrofuran / 6 h / -10 °C / Inert atmosphere

4.2: Cooling

5.1: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

6.1: sodium methylate / 1,4-dioxane; methanol / 3 h / -10 °C

7.1: 1,2-dimethoxyethane; water; tetrahydrofuran / 50 h / 20 °C

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; sodium methylate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water;