Technology Process of C22H32O2
There total 4 articles about C22H32O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
18-crown-6 ether; potassium hexamethylsilazane;
In
diethyl ether;
at 0 - 20 ℃;
for 18h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja109165f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.33 h / -78 °C / Inert atmosphere
1.2: 0.67 h / -78 - 0 °C / Inert atmosphere
2.1: n-butyllithium / diethyl ether; hexane / 0.02 h / -78 °C / Inert atmosphere
2.2: 0.5 h / -78 °C / Inert atmosphere
3.1: 18-crown-6 ether; potassium hexamethylsilazane / diethyl ether / 18 h / 0 - 20 °C / Inert atmosphere
With
n-butyllithium; oxalyl dichloride; 18-crown-6 ether; potassium hexamethylsilazane; dimethyl sulfoxide;
In
diethyl ether; hexane; dichloromethane;
3.1: oxy-Cope rearrangement;
DOI:10.1021/ja109165f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: zirconocene dichloride; diisobutylaluminium hydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
1.2: 0.5 h / -78 °C / Inert atmosphere
2.1: n-butyllithium / diethyl ether; hexane / 0.02 h / -78 °C / Inert atmosphere
2.2: 0.5 h / -78 °C / Inert atmosphere
3.1: 18-crown-6 ether; potassium hexamethylsilazane / diethyl ether / 18 h / 0 - 20 °C / Inert atmosphere
With
n-butyllithium; zirconocene dichloride; 18-crown-6 ether; potassium hexamethylsilazane; diisobutylaluminium hydride;
In
tetrahydrofuran; diethyl ether; hexane;
3.1: oxy-Cope rearrangement;
DOI:10.1021/ja109165f
