(E)-(6-benzyloxycarbonylamino)-2-hexenal

Base Information

• Chemical Name: (E)-(6-benzyloxycarbonylamino)-2-hexenal
• CAS No.: 1000806-50-7
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.294
• Mol file: 1000806-50-7.mol

Synonyms:(E)-(6-benzyloxycarbonylamino)-2-hexenal

Chemical Property of (E)-(6-benzyloxycarbonylamino)-2-hexenal

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-(6-benzyloxycarbonylamino)-2-hexenal

There total 2 articles about (E)-(6-benzyloxycarbonylamino)-2-hexenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

pent-4-enylcarbamic acid benzyl ester (86136-88-1) + acrolein (107-02-8,25068-14-8) → (E)-(6-benzyloxycarbonylamino)-2-hexenal (1000806-50-7)

Guidance literature:

[1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1021/ol702447y

Reference yield: 67.0%

trans-Crotonaldehyde (123-73-9,4170-30-3) + pent-4-enylcarbamic acid benzyl ester (86136-88-1) → (E)-(6-benzyloxycarbonylamino)-2-hexenal (1000806-50-7)

Guidance literature:

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 45 ℃; for 48h;

DOI:10.1021/jo800749t

Reference yield: 61.0%

(E)-(6-benzyloxycarbonylamino)-2-hexenal (1000806-50-7) → (2R)-N-benzyloxycarbonyl-2-(2-hydroxyethyl)pyrrolidine (1000806-60-9)

Guidance literature:

(E)-(6-benzyloxycarbonylamino)-2-hexenal; With benzoic acid; In chloroform; at -50 ℃; for 20h;

With sodium tetrahydroborate; In methanol; chloroform; at 0 ℃; for 0.5h; Further stages.;

DOI:10.1021/ol702447y

upstream raw materials:

pent-4-enylcarbamic acid benzyl ester

acrolein

trans-Crotonaldehyde

Downstream raw materials:

(2R)-N-benzyloxycarbonyl-2-(2-hydroxyethyl)pyrrolidine

(-)-(S)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylic acid benzyl ester

(R)-(N-benzyloxycarbonyl)-2-(2-oxoethyl)pyrrolidine

benzyl (S)-2-(2-oxoethyl)pyrrolidine-1-carboxylate