(S)-2-(aminomethyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxamide

Base Information

Chemical Name:(S)-2-(aminomethyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxamide
CAS No.:1361293-96-0
Molecular Formula:C₃₁H₃₁Cl₄N₃O₃
Molecular Weight:635.417
Hs Code.:

Synonyms:(S)-2-(aminomethyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxamide

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Chemical Property of (S)-2-(aminomethyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxamide

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Technology Process of (S)-2-(aminomethyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxamide

There total 16 articles about (S)-2-(aminomethyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1361294-00-9
(S)-tert-butyl 2-(aminomethyl)-3-(cyclopropyl(2,3-dichlorobenzyl)carbamoyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

: 1361293-96-0
(S)-2-(aminomethyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1361293-50-6
(S)-3-Amino-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-hydroxybutanamide

: 1361293-96-0
(S)-2-(aminomethyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 13 steps

1.1: methanol / 50 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / 1,4-dioxane / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; sodium iodide / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

4.1: sodium / toluene; methanol / 48 h / 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

5.2: 20 °C

6.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

7.1: sodium iodide; sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

7.2: 2.5 h / 55 °C / Inert atmosphere

8.1: hydrogenchloride / water; methanol / 1 h / 55 °C / Inert atmosphere

9.1: sodium hydrogencarbonate / 1,4-dioxane; water / 20 °C / Inert atmosphere

10.1: triethylamine / dichloromethane / 4 h / 0 °C / Inert atmosphere

11.1: sodium azide / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

12.1: triphenylphosphine / water; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

13.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium azide; sodium; sodium hydride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1361293-51-7
(S)-methyl 3-(4-(cyclopropyl(2,3-dichlorobenzyl)amino)-1-hydroxy-4-oxobutan-2-ylamino)propanoate

: 1361293-96-0
(S)-2-(aminomethyl)-N-cyclopropyl-N-(2,3-dichlorobenzyl)-4-(4-(2-(2,6-dichlorophenoxy)ethoxy)phenyl)-1,2,5,6-tetrahydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; sodium iodide / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

3.1: sodium / toluene; methanol / 48 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

4.2: 20 °C

5.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 150 °C / Inert atmosphere; Microwave irradiation

6.1: sodium iodide; sodium hydride / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

6.2: 2.5 h / 55 °C / Inert atmosphere

7.1: hydrogenchloride / water; methanol / 1 h / 55 °C / Inert atmosphere

8.1: sodium hydrogencarbonate / 1,4-dioxane; water / 20 °C / Inert atmosphere

9.1: triethylamine / dichloromethane / 4 h / 0 °C / Inert atmosphere

10.1: sodium azide / N,N-dimethyl-formamide / 5 h / 80 °C / Inert atmosphere

11.1: triphenylphosphine / water; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

12.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium azide; sodium; sodium hydride; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene;