(R)-4-(tert-butyldiphenylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-n,2-dimethylbutanamide

Base Information

Chemical Name:(R)-4-(tert-butyldiphenylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-n,2-dimethylbutanamide
CAS No.:913183-55-8
Molecular Formula:C₃₁H₄₁NO₃Si
Molecular Weight:503.757
Hs Code.:

Synonyms:(R)-4-(tert-butyldiphenylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-n,2-dimethylbutanamide

Suppliers and Price of (R)-4-(tert-butyldiphenylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-n,2-dimethylbutanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-4-(tert-butyldiphenylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-n,2-dimethylbutanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-4-(tert-butyldiphenylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-n,2-dimethylbutanamide

There total 2 articles about (R)-4-(tert-butyldiphenylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-n,2-dimethylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 126822-71-7
1-iodo-2-<(tert-butyldiphenylsilyl)oxy>ethane

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: 913183-55-8
(R)-4-(tert-butyldiphenylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-n,2-dimethylbutanamide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 1.33333h; Inert atmosphere;

1-iodo-2-<(tert-butyldiphenylsilyl)oxy>ethane; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 18h; optical yield given as %de; Inert atmosphere;
DOI:10.1002/anie.201102037

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 913183-55-8
(R)-4-(tert-butyldiphenylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-n,2-dimethylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2.5 h / 0 - 25 °C / Inert atmosphere

2.1: lithium chloride; diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1.25 h / -78 - 25 °C / Inert atmosphere

2.2: 17 h / -78 - 0 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.202101104

Reference yield: 96.0%

: 913183-55-8
(R)-4-(tert-butyldiphenylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-n,2-dimethylbutanamide

: 213740-15-9
(2R)-4-[1-(tert-butyl)-1,1-diphenylsilyl]oxy-2-methylbutan-1-ol

Guidance literature:: (R)-4-(tert-butyldiphenylsilyloxy)-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-n,2-dimethylbutanamide; With n-butyllithium; borane-ammonia complex; diisopropylamine; In tetrahydrofuran; hexane; at 0 - 23 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; hexane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1002/anie.201102037