methyl acryloyl-L-alanyl-L-phenylalanine

Base Information

• Chemical Name: methyl acryloyl-L-alanyl-L-phenylalanine
• CAS No.: 952312-44-6
• Molecular Formula: C₁₆H₂₀N₂O₄
• Molecular Weight: 304.346
• Mol file: 952312-44-6.mol

Synonyms:methyl acryloyl-L-alanyl-L-phenylalanine

Chemical Property of methyl acryloyl-L-alanyl-L-phenylalanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl acryloyl-L-alanyl-L-phenylalanine

There total 2 articles about methyl acryloyl-L-alanyl-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.5%

L-alanyl-L-phenylalanine methyl ester (40298-89-3,97336-13-5,102606-46-2,127214-08-8) + acryloyl chloride (814-68-6,25189-84-8) → methyl acryloyl-L-alanyl-L-phenylalanine (952312-44-6)

Guidance literature:

L-alanyl-L-phenylalanine methyl ester; With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere;

acryloyl chloride; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jacs.1c05659

Reference yield:

L-alanyl-L-phenylalanine (3061-90-3) → methyl acryloyl-L-alanyl-L-phenylalanine (952312-44-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / 20 °C

2: dimethylformamide / -10 - 20 °C

With hydrogenchloride; In N,N-dimethyl-formamide;

DOI:10.1080/00397910701481146

Reference yield: 76.0%

methyl acryloyl-L-alanyl-L-phenylalanine (952312-44-6) + 3-(2',3',4',6'-tetra-O-benzyl-α-D-galactopyranosyl)prop-1-ene (82659-55-0) → C51H56N2O9 + C72H76O10

Guidance literature:

substituted Grubbs-type ruthenium carbene complex; In dichloromethane; at 40 ℃; for 18h;

DOI:10.1080/00397910701481146

upstream raw materials:

L-alanyl-L-phenylalanine methyl ester

acryloyl chloride

L-alanyl-L-phenylalanine