tert-butyl (2R)-2-aminobutanoate

Base Information

• Chemical Name: tert-butyl (2R)-2-aminobutanoate
• CAS No.: 313994-32-0
• Molecular Formula: C8H17 N O2
• Molecular Weight: 195.69
• Hs Code.: 2922498590
• European Community (EC) Number: 829-274-7
• Mol file: 313994-32-0.mol

Synonyms:H-D-Abu-OtBu;tert-butyl (2R)-2-aminobutanoate;313994-32-0;(R)-tert-Butyl 2-aminobutanoate;tert-Butyl (R)-2-aminobutanoate;SCHEMBL1952044;AKOS013465886;CS-0311611;EN300-109686;Z1436181069

Chemical Property of tert-butyl (2R)-2-aminobutanoate

Chemical Property:

• PSA: 52.32000
• LogP: 2.56770
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 159.125928785
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

(R)-tert-Butyl2-Aminobutanoate ^*data from reagent suppliers

Safty Information:

• Statements: 52

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C(=O)OC(C)(C)C)N
• Isomeric SMILES: CC[C@H](C(=O)OC(C)(C)C)N

Technology Process of tert-butyl (2R)-2-aminobutanoate

There total 1 articles about tert-butyl (2R)-2-aminobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

acetic acid tert-butyl ester (540-88-5) + (R)-2-aminobutyric acid (2623-91-8) → (R)-tert-butyl 2-aminobutanoate (313994-32-0)

Guidance literature:

With perchloric acid; at 20 ℃; for 48h;

DOI:10.1016/j.bmc.2015.03.078

Reference yield: 96.0%

(R)-tert-butyl 2-aminobutanoate (313994-32-0) + Boc-D-Tyr(2-BrZ)-OH (81189-61-9) → tert-butyl (R)-2-((R)-3-(4-((((2-bromobenzyl)oxy)carbonyl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)propanamido)butanoate

Guidance literature:

With pyridine; FI-750-M; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; at 60 ℃; for 0.25h; Sealed tube;

DOI:10.1021/acs.orglett.0c01676

Reference yield: 91.0%

(R)-tert-butyl 2-aminobutanoate (313994-32-0) + Fmoc-His(Trt)-OH (109425-51-6) → tert-butyl (R)-2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)butanoate

Guidance literature:

With pyridine; FI-750-M; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In water; at 60 ℃; for 0.25h; Sealed tube;

DOI:10.1021/acs.orglett.0c01676

upstream raw materials:

acetic acid tert-butyl ester

(R)-2-aminobutyric acid

Downstream raw materials:

tert-butyl (R)-N-(4-methoxyphenylsulfonyl)aminobutanoate

tert-butyl (R)-N-(4-methoxyphenylsulfonyl)-N-(3-pyridylmethyl)-2-aminobutanoate

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