2-(4-(4-(2,4-dimethylphenylsulfonamido)-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Base Information

Chemical Name:2-(4-(4-(2,4-dimethylphenylsulfonamido)-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid
CAS No.:1080521-05-6
Molecular Formula:C₂₆H₂₃F₃N₂O₆S
Molecular Weight:548.54
Hs Code.:

Synonyms:2-(4-(4-(2,4-dimethylphenylsulfonamido)-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

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Chemical Property of 2-(4-(4-(2,4-dimethylphenylsulfonamido)-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

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Technology Process of 2-(4-(4-(2,4-dimethylphenylsulfonamido)-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

There total 6 articles about 2-(4-(4-(2,4-dimethylphenylsulfonamido)-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080522-03-7
methyl 2-(4-(4-(2,4-dimethylphenylsulfonamido)-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

: 1080521-05-6
2-(4-(4-(2,4-dimethylphenylsulfonamido)-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

Reference yield:

: 1080521-94-3
methyl 2-(4-(2-bromo-4-nitro-1H-indol-5-yloxy)-3-methoxyphenyl)acetate

: 1080521-05-6
2-(4-(4-(2,4-dimethylphenylsulfonamido)-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: dmap / acetonitrile / 20 °C

2: copper(l) iodide; palladium dichloride / N,N-dimethyl-formamide / 1 h / 80 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

5: pyridine / 20 °C

6: lithium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

With pyridine; dmap; lithium hydroxide; water; hydrogen; trifluoroacetic acid; copper(l) iodide; palladium 10% on activated carbon; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1080523-14-3
methyl 2-(3-methoxy-4-(4-nitro-2-oxoindolin-5-yloxy)phenyl)acetate

: 1080521-05-6
2-(4-(4-(2,4-dimethylphenylsulfonamido)-2-(trifluoromethyl)-1H-indol-5-yloxy)-3-methoxyphenyl)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 1 h / 90 °C

1.2: 2 h / 90 °C

1.3: pH 8

2.1: dmap / acetonitrile / 20 °C

3.1: copper(l) iodide; palladium dichloride / N,N-dimethyl-formamide / 1 h / 80 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C

6.1: pyridine / 20 °C

7.1: lithium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

With pyridine; dmap; lithium hydroxide; water; hydrogen; trifluoroacetic acid; phosphorus(V) oxybromide; copper(l) iodide; palladium 10% on activated carbon; palladium dichloride; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;