(3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone

Base Information

• Chemical Name: (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone
• CAS No.: 1407991-69-8
• Molecular Formula: C₁₉H₁₆N₂O₃
• Molecular Weight: 320.348
• Mol file: 1407991-69-8.mol

Synonyms:(3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone

Chemical Property of (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone

There total 12 articles about (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) + 3-(4-nitrophenyl)-1-(2-pyridyl)-2-propenone (18451-69-9,24582-78-3) → (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone (1407991-69-8) + (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone + (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone

Guidance literature:

With potassium dihydrogenphosphate; 5′-GGTTGGTGTGG-3′ G-triplex; potassium chloride; copper(II) nitrate; In acetonitrile; at 4 ℃; for 24h; pH=7; Overall yield = 86 %; Optical yield = 28 %ee; stereoselective reaction;

DOI:10.1016/j.catcom.2015.09.012

Reference yield:

cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) + (2E)-3-(4-nitrophenyl)-1-(pyridin-2-yl)prop-2-en-1-one (18451-69-9) → (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone (1407991-69-8) + (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone

Guidance literature:

With copper(II) nitrate trihydrate; (E)-1,1'-(((diazene-1,2-diylbis(4,1-phenylene))bis(oxy))bis(ethane-2,1-diyl))bis(1-methylpiperidin-1-ium); potassium chloride; 5'-d(TGGTGGTGGTGGTTGTGGTGGTGGTGTT)-3'; sodium chloride; In aq. buffer; at 4 ℃; for 24h; pH=6.5; Reagent/catalyst; Optical yield = 78 percent ee; stereoselective reaction;

DOI:10.1016/j.cclet.2020.12.047

Reference yield:

cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) + (2E)-3-(4-nitrophenyl)-1-(pyridin-2-yl)prop-2-en-1-one (18451-69-9) → (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone (1407991-69-8) + (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)-methanone + (3-(4-nitrophenyl)bicyclo[2.2.1]hept-5-en-2-yl)(pyridin-2-yl)methanone

Guidance literature:

With copper(II) nitrate trihydrate; C₃₉H₄₄N₈O₅; potassium chloride; 5'-d(TGGTGGTGGTGGTTGTGGTGGTGGTGTT)-3'; sodium chloride; In aq. buffer; at 4 ℃; for 24h; pH=6.5; Reagent/catalyst; stereoselective reaction;

DOI:10.1016/j.cclet.2020.12.047

upstream raw materials:

cyclopenta-1,3-diene

(2E)-3-(4-nitrophenyl)-1-(pyridin-2-yl)prop-2-en-1-one

3-(4-nitrophenyl)-1-(2-pyridyl)-2-propenone

4-nitrobenzaldehdye