2,6-difluoro-N-[5-(2-hydroxy-1-methyl-ethylidene)-5,6,7,8-tetrahydro-naphthalen-2-yl]-benzamide

Base Information

Chemical Name:2,6-difluoro-N-[5-(2-hydroxy-1-methyl-ethylidene)-5,6,7,8-tetrahydro-naphthalen-2-yl]-benzamide
CAS No.:1049666-07-0
Molecular Formula:C₂₀H₁₉F₂NO₂
Molecular Weight:343.373
Hs Code.:

Synonyms:2,6-difluoro-N-[5-(2-hydroxy-1-methyl-ethylidene)-5,6,7,8-tetrahydro-naphthalen-2-yl]-benzamide

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Chemical Property of 2,6-difluoro-N-[5-(2-hydroxy-1-methyl-ethylidene)-5,6,7,8-tetrahydro-naphthalen-2-yl]-benzamide

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Technology Process of 2,6-difluoro-N-[5-(2-hydroxy-1-methyl-ethylidene)-5,6,7,8-tetrahydro-naphthalen-2-yl]-benzamide

There total 5 articles about 2,6-difluoro-N-[5-(2-hydroxy-1-methyl-ethylidene)-5,6,7,8-tetrahydro-naphthalen-2-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1049666-03-6
2-[6-(2,6-difluoro-benzoylamino)-3,4-dihydro-2H-naphthalen-1-ylidene]-propionic acid

: 1049666-07-0
2,6-difluoro-N-[5-(2-hydroxy-1-methyl-ethylidene)-5,6,7,8-tetrahydro-naphthalen-2-yl]-benzamide

Guidance literature:: 2-[6-(2,6-difluoro-benzoylamino)-3,4-dihydro-2H-naphthalen-1-ylidene]-propionic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With water; In tetrahydrofuran;

Reference yield:

: 1049666-13-8
2,6-difluoro-N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)benzamide

: 1049666-07-0
2,6-difluoro-N-[5-(2-hydroxy-1-methyl-ethylidene)-5,6,7,8-tetrahydro-naphthalen-2-yl]-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1 h

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1.5 h / -78 - 0 °C

2.2: -78 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

With lithium aluminium tetrahydride; tert.-butyl lithium; sodium hydride; In tetrahydrofuran; pentane;

Reference yield:

: 2,6-difluoro-N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)benzamide sodium salt

: 1049666-07-0
2,6-difluoro-N-[5-(2-hydroxy-1-methyl-ethylidene)-5,6,7,8-tetrahydro-naphthalen-2-yl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1.5 h / -78 - 0 °C

1.2: -78 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

With lithium aluminium tetrahydride; tert.-butyl lithium; In tetrahydrofuran; pentane;