C₃₉H₆₆N₄O₄SSi

Base Information

• Chemical Name: C₃₉H₆₆N₄O₄SSi
• CAS No.: 1261360-01-3
• Molecular Formula: C₃₉H₆₆N₄O₄SSi
• Molecular Weight: 715.129
• Mol file: 1261360-01-3.mol

Synonyms:C₃₉H₆₆N₄O₄SSi

Chemical Property of C₃₉H₆₆N₄O₄SSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₉H₆₆N₄O₄SSi

There total 29 articles about C₃₉H₆₆N₄O₄SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C32H62O5Si (1261359-85-6) + 1-Phenyl-1H-tetrazole-5-thiol (86-93-1) → C39H66N4O4SSi (1261360-01-3)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

DOI:10.1021/ol1028699

Reference yield:

(2S,6S)-6-hexyl-2-(hydroxymethyl)tetrahydropyran (1261359-78-7) → C39H66N4O4SSi (1261360-01-3)

Guidance literature:

Multi-step reaction with 10 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

1.2: 1.33 h / -78 - -20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 2 h

3.1: 4-Bromobenzoic acid; di-isopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 16 h / 20 °C

3.2: 4 h / 20 °C

4.1: 1H-imidazole / dichloromethane / 16 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 - -50 °C

5.2: 1.5 h

6.1: sodium acetate; toluene-4-sulfonic acid hydrazide / 1,2-dimethoxyethane; water / 4 h / Reflux

7.1: methanesulfonyl chloride; triethylamine / dichloromethane / 1 h / 0 °C

7.2: 22 h / 0 - 20 °C

8.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C

9.1: 20 % Pd(OH)2/C; hydrogen / ethanol / 1.5 h / 20 °C

10.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 0 - 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; n-butyllithium; oxalyl dichloride; 4-Bromobenzoic acid; di-isopropyl azodicarboxylate; 20 % Pd(OH)2/C; hydrogen; sodium acetate; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; toluene-4-sulfonic acid hydrazide; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; hexane; dichloromethane; water;

DOI:10.1021/ol1028699

Reference yield:

(2S,6S)-6-hexyltetrahydro-2H-pyran-2-carbaldehyde (1261359-93-6) → C39H66N4O4SSi (1261360-01-3)

Guidance literature:

Multi-step reaction with 9 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 2 h

2.1: 4-Bromobenzoic acid; di-isopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 16 h / 20 °C

2.2: 4 h / 20 °C

3.1: 1H-imidazole / dichloromethane / 16 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 - -50 °C

4.2: 1.5 h

5.1: sodium acetate; toluene-4-sulfonic acid hydrazide / 1,2-dimethoxyethane; water / 4 h / Reflux

6.1: methanesulfonyl chloride; triethylamine / dichloromethane / 1 h / 0 °C

6.2: 22 h / 0 - 20 °C

7.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C

8.1: 20 % Pd(OH)2/C; hydrogen / ethanol / 1.5 h / 20 °C

9.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 4 h / 0 - 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; n-butyllithium; 4-Bromobenzoic acid; di-isopropyl azodicarboxylate; 20 % Pd(OH)2/C; hydrogen; sodium acetate; methanesulfonyl chloride; triethylamine; toluene-4-sulfonic acid hydrazide; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; hexane; dichloromethane; water;

DOI:10.1021/ol1028699

upstream raw materials:

C₁₉H₂₈O₂

C₁₉H₃₀O₄

C₃₁H₅₈O₄Si₂

C₂₅H₄₄O₄Si

Downstream raw materials:

C₃₉H₆₆N₄O₆SSi