Technology Process of N-{[6-hydroxy-2-(phenyloxy)-5-quinoxalinyl]carbonyl}glycine
There total 9 articles about N-{[6-hydroxy-2-(phenyloxy)-5-quinoxalinyl]carbonyl}glycine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-Hydroxy-2-(phenyloxy)-5-quinoxalinecarboxylic acid; glycine ethyl ester hydrochloride;
With
triethylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
With
water; sodium hydroxide;
In
ethanol;
at 20 ℃;
for 0.25h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sulfuric acid; nitric acid / 0 - 20 °C
2.1: ammonium hydroxide / ethanol; water / 20 °C
3.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C
4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2585.81 Torr
5.1: toluene; acetonitrile / 0.25 h / 20 °C
6.1: trichlorophosphate / Reflux
7.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 150 °C / Microwave irradiation
8.1: boron tribromide / dichloromethane / 20 °C
9.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C
9.2: 0.25 h / 20 °C
With
ammonium hydroxide; sulfuric acid; hydrogen; nitric acid; boron tribromide; sodium hydride; caesium carbonate; triethylamine; HATU; trichlorophosphate;
palladium 10% on activated carbon;
In
ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / mineral oil / 1 h / 0 - 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2585.81 Torr
3.1: toluene; acetonitrile / 0.25 h / 20 °C
4.1: trichlorophosphate / Reflux
5.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 150 °C / Microwave irradiation
6.1: boron tribromide / dichloromethane / 20 °C
7.1: triethylamine; HATU / N,N-dimethyl-formamide / 20 °C
7.2: 0.25 h / 20 °C
With
hydrogen; boron tribromide; sodium hydride; caesium carbonate; triethylamine; HATU; trichlorophosphate;
palladium 10% on activated carbon;
In
dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
