2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yldiphenylphosphine oxide

Base Information

• Chemical Name: 2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yldiphenylphosphine oxide
• CAS No.: 237752-48-6
• Molecular Formula: C₁₈H₁₈NO₂P
• Molecular Weight: 311.32
• Mol file: 237752-48-6.mol

Synonyms:2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yldiphenylphosphine oxide

Chemical Property of 2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yldiphenylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yldiphenylphosphine oxide

There total 3 articles about 2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yldiphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-hydroxy-P,P-diphenylphosphinic amide (73452-52-5) + cyclohexa-1,3-diene (1165952-91-9) → 2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yldiphenylphosphine oxide (237752-48-6)

Guidance literature:

With pyridine; copper(l) chloride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/ol301414k

Reference yield: 87.0%

cyclohexa-1,3-diene (1165952-91-9) + C12H10NO2P (237752-46-4) → 2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yldiphenylphosphine oxide (237752-48-6)

Guidance literature:

DOI:10.1021/ja9908016

Reference yield:

N-hydroxy-P,P-diphenylphosphinic amide (73452-52-5) → 2-oxa-3-azabicyclo[2.2.2]oct-5-en-3-yldiphenylphosphine oxide (237752-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Bu₄NIO₄

2: 87 percent

With tetrabutylammonium periodite;

DOI:10.1021/ja9908016

upstream raw materials:

cyclohexa-1,3-diene

C₁₂H₁₀NO₂P

N-hydroxy-P,P-diphenylphosphinic amide

Downstream raw materials:

(1S*,4R*)-4-aminocyclohex-2-enol