tert-butyl 2-(2-acetoxy-5-bromobenzamido)-4-phenylbenzoate

Base Information

• Chemical Name: tert-butyl 2-(2-acetoxy-5-bromobenzamido)-4-phenylbenzoate
• CAS No.: 1237514-87-2
• Molecular Formula: C₂₆H₂₄BrNO₅
• Molecular Weight: 510.384
• Mol file: 1237514-87-2.mol

Synonyms:tert-butyl 2-(2-acetoxy-5-bromobenzamido)-4-phenylbenzoate

Chemical Property of tert-butyl 2-(2-acetoxy-5-bromobenzamido)-4-phenylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(2-acetoxy-5-bromobenzamido)-4-phenylbenzoate

There total 2 articles about tert-butyl 2-(2-acetoxy-5-bromobenzamido)-4-phenylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-amino-4-phenylbenzoate (890316-40-2) + 2-acetoxy-5-bromo-benzoyl chloride (5485-91-6) → tert-butyl 2-(2-acetoxy-5-bromobenzamido)-4-phenylbenzoate (1237514-87-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 0.5h; Cooling with ice;

Reference yield:

2-acetyloxy-5-bromobenzoic acid (1503-53-3) → tert-butyl 2-(2-acetoxy-5-bromobenzamido)-4-phenylbenzoate (1237514-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: pyridine / dichloromethane / 0.5 h / 20 °C / Cooling with ice

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

tert-butyl 2-(2-acetoxy-5-bromobenzamido)-4-phenylbenzoate (1237514-87-2) + phenylboronic acid (98-80-6) → C32H29NO5 (1237519-45-7)

Guidance literature:

tert-butyl 2-(2-acetoxy-5-bromobenzamido)-4-phenylbenzoate; phenylboronic acid; With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; for 0.75h; Inert atmosphere; Reflux;

With potassium carbonate; In 1,2-dimethoxyethane; water; at 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

2-acetyloxy-5-bromobenzoic acid

tert-butyl 2-amino-4-phenylbenzoate

2-acetoxy-5-bromo-benzoyl chloride

Downstream raw materials:

2-(5-bromo-2-hydroxybenzamido)-4-phenylbenzoic acid

tert-butyl 2-(2-acetoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamido)-4-phenylbenzoate

C₃₂H₂₉NO₅

tert-butyl 2-(2-hydroxy-5-phenylbenzamido)-4-phenylbenzoate