<7-<1-<(1S)-1-phenylethyl>carbamoylpropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate

Base Information

• Chemical Name: <7-<1-<(1S)-1-phenylethyl>carbamoylpropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate
• CAS No.: 127319-02-2
• Molecular Formula: C₂₅H₃₀N₂O₆
• Molecular Weight: 454.523
• Mol file: 127319-02-2.mol

Synonyms:<7-<1-<(1S)-1-phenylethyl>carbamoylpropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate

Chemical Property of <7-<1-<(1S)-1-phenylethyl>carbamoylpropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <7-<1-<(1S)-1-phenylethyl>carbamoylpropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate

There total 3 articles about <7-<1-<(1S)-1-phenylethyl>carbamoylpropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

<7-<1-<(1S)-1-phenylethyl>carbamoyl-1-propenyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate (127319-01-1) → <7-<1-<(1S)-1-phenylethyl>carbamoylpropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate (127319-02-2)

Guidance literature:

With hydrogen; nickel; In ethanol; acetic acid; for 11h; under 760 Torr; Ambient temperature; Irradiation;

DOI:10.1248/cpb.37.3382

Reference yield:

<7-<(1R)-1-<(1S)-1-phenylethyl>carbamoyl-1-hydroxypropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate (127319-00-0) → <7-<1-<(1S)-1-phenylethyl>carbamoylpropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate (127319-02-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 6 h / 50 °C

2: 290 mg / hydrogen / Raney Ni / acetic acid; ethanol / 11 h / 760 Torr / Ambient temperature; Irradiation

With hydrogen; triphenylphosphine; diethylazodicarboxylate; nickel; In tetrahydrofuran; ethanol; acetic acid;

DOI:10.1248/cpb.37.3382

Reference yield:

(R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide (127318-98-3) → <7-<1-<(1S)-1-phenylethyl>carbamoylpropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate (127319-02-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / pyridine / 24 h / Ambient temperature

2: 91 percent / Ph₃P, diethyl azodicarboxylate / tetrahydrofuran / 6 h / 50 °C

3: 290 mg / hydrogen / Raney Ni / acetic acid; ethanol / 11 h / 760 Torr / Ambient temperature; Irradiation

With pyridine; hydrogen; triphenylphosphine; diethylazodicarboxylate; nickel; In tetrahydrofuran; ethanol; acetic acid;

DOI:10.1248/cpb.37.3382

upstream raw materials:

<7-<1-<(1S)-1-phenylethyl>carbamoyl-1-propenyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate

<7-<(1R)-1-<(1S)-1-phenylethyl>carbamoyl-1-hydroxypropyl>-1,1-(ethylenedioxy)-5-oxo-1,2,3,5-tetrahydroindolizin-6-yl>methyl acetate

(R)-α-ethyl-α-hydroxy-1,1-(ethylenedioxy)-6-hydroxymethyl-5-oxo-1,2,3,5-tetrahydroindolizine-7-acetamide