6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazine-3-carboxylic acid pyridin-4-ylamide

Base Information

Chemical Name:6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazine-3-carboxylic acid pyridin-4-ylamide
CAS No.:1040376-94-0
Molecular Formula:C₁₈H₁₄Cl₂FN₅O₂
Molecular Weight:422.246
Hs Code.:

Synonyms:6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazine-3-carboxylic acid pyridin-4-ylamide

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Chemical Property of 6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazine-3-carboxylic acid pyridin-4-ylamide

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Technology Process of 6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazine-3-carboxylic acid pyridin-4-ylamide

There total 8 articles about 6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazine-3-carboxylic acid pyridin-4-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₀Cl₂FN₅O₆

: 1040376-94-0
6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazine-3-carboxylic acid pyridin-4-ylamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 504-24-5
4-aminopyridine

: C₂₃H₂₅Cl₃FN₃O₆

: 1040376-94-0
6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazine-3-carboxylic acid pyridin-4-ylamide

Guidance literature:: 4-aminopyridine; C₂₃H₂₅Cl₃FN₃O₆; With triethylamine; In dichloromethane; at 0 - 20 ℃;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium carbonate; In dichloromethane; water; pH=8;

Reference yield:

: 1040376-43-9
6-chloro-4-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazin-3-ylamine

: 1040376-94-0
6-amino-5-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridazine-3-carboxylic acid pyridin-4-ylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / N,N-dimethyl-formamide / 20 °C

2.1: sodium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 90 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

3.2: pH 5

4.1: oxalyl dichloride; triethylamine / dichloromethane / 0 - 20 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

5.2: 2 h / 20 °C

5.3: pH 8

With dmap; oxalyl dichloride; water; sodium acetate; triethylamine; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;