C₄₀H₅₁NO₁₀

Base Information

• Chemical Name: C₄₀H₅₁NO₁₀
• CAS No.: 1404078-88-1
• Molecular Formula: C₄₀H₅₁NO₁₀
• Molecular Weight: 705.846
• Mol file: 1404078-88-1.mol

Synonyms:C₄₀H₅₁NO₁₀

Chemical Property of C₄₀H₅₁NO₁₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₀H₅₁NO₁₀

There total 18 articles about C₄₀H₅₁NO₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

C46H65NO10Si (1404078-86-9) → C40H51NO10 (1404078-88-1) + C32H43NO9 (1404078-90-5)

Guidance literature:

With pyridine; hydrogenchloride; hydrogen fluoride; In tetrahydrofuran; water; at 20 ℃; for 14h;

DOI:10.1039/c2ob26256h

Reference yield:

O-(4-methoxybenzyl)-trichloroacetimidate (89238-99-3) → C40H51NO10 (1404078-88-1)

Guidance literature:

Multi-step reaction with 15 steps

1.1: camphor-10-sulfonic acid / dichloromethane / 16 h / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / -78 - -20 °C

2.2: 0.5 h / 20 °C

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

4.1: titanium tetrachloride / dichloromethane / 0.33 h / -50 °C

4.2: 2 h / -40 °C

4.3: 2 h / -78 °C

5.1: 2,6-dimethylpyridine / dichloromethane / 3 h / -78 - 20 °C

6.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

7.2: 72 h / 20 °C

8.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 °C

9.1: copper(ll) bromide; hexamethylenetetramine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2 h / 20 °C

10.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.75 h / -78 °C

11.1: potassium carbonate / methanol / 0 - 20 °C

12.1: Schwartz's reagent / tetrahydrofuran / 1 h / 0 °C

12.2: 0.67 h / -78 °C / Darkness

13.1: tert.-butyl lithium / pentane; diethyl ether / 1 h / -78 °C / Inert atmosphere

13.2: 0.25 h / -78 °C

13.3: 3 h / -78 °C

14.1: dmap; pyridine / dichloromethane / 16 h / 20 °C

15.1: pyridine; hydrogenchloride; hydrogen fluoride / tetrahydrofuran; water / 14 h / 20 °C

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; dmap; Schwartz's reagent; diethylamino-sulfur trifluoride; hexamethylenetetramine; camphor-10-sulfonic acid; hydrogen fluoride; dihydrogen peroxide; tert.-butyl lithium; titanium tetrachloride; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; toluene; pentane;

DOI:10.1039/c2ob26256h

Reference yield:

(2S,3R)-3-(4-methoxybenzyloxy)-2-methylpentanal (627511-81-3) → C40H51NO10 (1404078-88-1) + C32H43NO9 (1404078-90-5)

Guidance literature:

Multi-step reaction with 12 steps

1.1: titanium tetrachloride / dichloromethane / 0.33 h / -50 °C

1.2: 2 h / -40 °C

1.3: 2 h / -78 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 3 h / -78 - 20 °C

3.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

4.2: 72 h / 20 °C

5.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 °C

6.1: copper(ll) bromide; hexamethylenetetramine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2 h / 20 °C

7.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.75 h / -78 °C

8.1: potassium carbonate / methanol / 0 - 20 °C

9.1: Schwartz's reagent / tetrahydrofuran / 1 h / 0 °C

9.2: 0.67 h / -78 °C / Darkness

10.1: tert.-butyl lithium / pentane; diethyl ether / 1 h / -78 °C / Inert atmosphere

10.2: 0.25 h / -78 °C

10.3: 3 h / -78 °C

11.1: dmap; pyridine / dichloromethane / 16 h / 20 °C

12.1: pyridine; hydrogenchloride; hydrogen fluoride / tetrahydrofuran; water / 14 h / 20 °C

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; dmap; Schwartz's reagent; diethylamino-sulfur trifluoride; hexamethylenetetramine; hydrogen fluoride; dihydrogen peroxide; tert.-butyl lithium; titanium tetrachloride; diisobutylaluminium hydride; potassium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene; pentane;

DOI:10.1039/c2ob26256h

upstream raw materials:

(2S,3R)-3-(4-methoxybenzyloxy)-2-methylpentanal

(3S,4R,5R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-4-methylheptanoic acid

methyl [2-(2S,3R,4R)-2-(tert-butyldimethylsilyloxy)-[4-(4-methoxybenzyloxy)-3-methylhexyl]]oxazol-4-carboxylate

C₃₉H₄₇NO₆S