8-acetyl-4-(3-chlorophenyl)-1,6,7,8-tetrahydro-1,3-dimethylpyrazolo<3,4-e><1,4>diazepine hydrochloride

Base Information

Chemical Name:8-acetyl-4-(3-chlorophenyl)-1,6,7,8-tetrahydro-1,3-dimethylpyrazolo<3,4-e><1,4>diazepine hydrochloride
CAS No.:54454-18-1
Molecular Formula:C₁₆H₁₇ClN₄O*ClH
Molecular Weight:353.251
Hs Code.:

Synonyms:8-acetyl-4-(3-chlorophenyl)-1,6,7,8-tetrahydro-1,3-dimethylpyrazolo<3,4-e><1,4>diazepine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-acetyl-4-(3-chlorophenyl)-1,6,7,8-tetrahydro-1,3-dimethylpyrazolo<3,4-e><1,4>diazepine hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 8-acetyl-4-(3-chlorophenyl)-1,6,7,8-tetrahydro-1,3-dimethylpyrazolo<3,4-e><1,4>diazepine hydrochloride

There total 3 articles about 8-acetyl-4-(3-chlorophenyl)-1,6,7,8-tetrahydro-1,3-dimethylpyrazolo<3,4-e><1,4>diazepine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 51022-73-2
4-(3-chloro-phenyl)-1,3-dimethyl-1,6,7,8-tetrahydro-pyrazolo[3,4-e][1,4]diazepine

: 108-24-7
acetic anhydride

: 54454-18-1
8-acetyl-4-(3-chlorophenyl)-1,6,7,8-tetrahydro-1,3-dimethylpyrazolo<3,4-e><1,4>diazepine hydrochloride

Guidance literature:: In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm00140a013

Reference yield:

: 58011-00-0
(1,3-dimethyl-5-hydroxy-1H-pyrazol-4-yl)(3-chlorophenyl)methanone

: 54454-18-1
8-acetyl-4-(3-chlorophenyl)-1,6,7,8-tetrahydro-1,3-dimethylpyrazolo<3,4-e><1,4>diazepine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / POCl₃ / 6 h / Heating

2: 50 percent / 20 h / Heating

3: 85 percent / CH₂Cl₂ / 16 h / 20 °C

With trichlorophosphate; In dichloromethane;
DOI:10.1021/jm00140a013

Reference yield:

: 29938-75-8
(5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)(3-chlorophenyl)methanone

: 54454-18-1
8-acetyl-4-(3-chlorophenyl)-1,6,7,8-tetrahydro-1,3-dimethylpyrazolo<3,4-e><1,4>diazepine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / 20 h / Heating

2: 85 percent / CH₂Cl₂ / 16 h / 20 °C

In dichloromethane;
DOI:10.1021/jm00140a013